The Comparison of Gestational Diabetes Mellitus Screening between the One Step Method and the Two Step Method

Abstract

This research aimed to compare the results of gestational diabetes mellitus (DMG) screening based on the
One Step and Two Step method. This research was a cross-sectional study conducted in pregnant women
24-28 weeks of gestation who meet the research criteria. The diagnosis of gestational diabetes using the
One Step and Two Step method was each carried out on 53 pregnant women so that the total sample of
the research was 106 pregnant women. The results showed that 28.3% of pregnant women (15/53) were
diagnosed with DMG with the One Step method compared with 3.8% (2/53) of pregnant women diagnosed
by the Two Step method. There was a significant difference (p <0.05) between the diagnosis results of
the two DMG diagnosis method. Further analysis of DMG risk factors showed that the highest positive
likelihood ratio (LR +) was found in the history of macrosomia with LR + = 4.45 with the One Step method
while the highest LR + for the Two Step method was found in obesity factors for pregnant women with
LR + = 6.57. The highest positive predictive value (PPV) for the One Step method of 46.70% was found
in pregnant women with risk factors for obesity while the Two Step method was found in pregnant women
with a history of DM (PPV = 100%). Pregnant women diagnosed with DMG were significantly greater in the
One Step method than the Two Step method. History of macrosomia (is found) as a risk factor for pregnant
women diagnosed with DMG with the One Step method, while a history of DM for the Two Step method.