Mode of Actions of Bisphosphonates in Dental Implant Procedure: An Overview

Abstract

Bisphosphonates (BP) are the most commonly used drug forthe past few years for the treatment of various
types of bone disorders and malignancies. Osteonecrosis of the jaw (ONJ) is most devitalizing but still not
has been properly acknowledged as of now. These drugs suppress bone turnover by decreasing osteoclastic
activity. This article points in featuring the key and pharmaco-physiological system of activity of both
N2 and non N2 bisphosphonates on bone and activity of bisphosphonates on dental implants, particularly
their commitment in success of the implant and the present suggestions and rules for implant treatment in
patients who are on bisphosphonate therapy. This article also includes the prevention and management for
decreasing the cumulative IV bisphosphonate dose, stoppage of bisphosphonates before any invasive dental
treatment, and in ONJ using serum beta-CTX-1 in assessment of risk. “Drug Holiday” for the invasive dental
procedure is incorporated as well.