Changes in Interleukins and Follicle Stimulating Hormone in Toxoplasmosis Male Patients

Abstract

In several countries there are endemic of parasitic diseases, specifically in developing countries, several
studies investigated that toxoplasmosis is related with sterility of male. Aims of study are assessment of antiToxoplasma IgG antibodies in patient’s serum and their relation with interleukins and FSH hormone. IL-6
stimulates antibody production and extend effect of proinflammatory by stimulating the production of acute
phase proteins. IL-10 and IL-12 control the immune response type. Cytokine synthesis is inhibits by the
former and by blocking the IL-6 and TNF-? production, the response with involvement of Th2 and activation
of B cells has an advantage. Detection for the toxoplasmosis which is based on toxo IgG , interleukins and
FSH used the classic ELISA technique that based on immunoassay system using fluorescence technology
and antigen antibody interaction. They were found in 1 (3.03%) of azoospermic patients and 4(12.12%)
of oligozoospermic patients, while the negative results found in 32(96.97%) of azoospermic patients and
29(87.88%) of oligozoospermic patients. The control group had 34(100%) negative results in toxoplasmosis.
The mean serum levels of IL-6 and IL-17 (pg / ml) increased significantly in patients with Toxoplasma gondii
compared to the control group (237.97±9.09 pg / ml 285.52±12.45and pg / ml, respectively; p<0.0001) . In
this study, it has been concluded that infection with T. gondii can effect on the level of the interleukins and
FSH in infertile couples.