The Role of EMMPRIN in Perirenal Fat Invasion Clear Cell Renal Cell Carcinoma

Abstract

Renal Cell Carcinoma (RCC) is a common malignancy of the kidney, and Clear Cell Renal Cell Carcinoma
(CCRCC) is the most common type. Accurate prediction of prognosis is valuable for therapy and follow
up. EMMPRIN is a transmembrane protein of the immunoglobulin family and is associated with tumour
proliferation, invasion and metastasis. This study aims to prove the role of EMMPRIN in perirenal fat
invasion CCRCC. This analytic observational study with a cross-sectional approach conducted in Anatomical
Pathology Institute of Dr. Soetomo Hospital, Surabaya that used 44 samples of paraffin blocks from radical
nephrectomy preparations for CCRCC patients at the period of January 2013-December 2018, which were
divided based on perirenal fat invasion status. The analyzed was using Spearman test. EMMPRIN expression
is positively correlated with perirenal fat invasiveness (p = 0.019) in clear cell renal cell carcinoma.
EMMPRIN expression is related with perirenal fat invasiveness, in clear cell renal cell carcinoma.