Potential Stem Cells of Oral Origin- A review on Induced Pluripotent Stem Cell Technology

Authors

  • Keerthi Narayan. V
  • Vasumathi.D
  • Pavithra.D
  • NirmalFamilaBettie

DOI:

https://doi.org/10.37506/ijfmt.v15i2.14312

Keywords:

Mesenchymal Stem Cells, Nuclear Reprogramming, Osteogenic Potential, Retroviruses, Somatic Cells, Transcription Factors.

Abstract

Mesenchymal stem cells are isolated from multiple tissues, such as bone marrow, peripheral blood,
umbilical cord blood, adult connective tissue, dental tissues, placenta, and amniotic membrane. Oral
derived mesenchymal stem cells (OMSC’s) are multipotent cells, though differentiates into odontoblast,
cementoblast, osteoblast, chondrocyte, adipocyte, melanocyte, endothelial cell hepatocyte, myoblast and
neural cell but shows limited differentiating into only these specific types of cells or mesenchymal origin
cells. Induced pluripotent stem cells (iPSC’s) are the potential stem cells induced through reprogramming
such somatic cells genetically by presenting with distinct or causative factors. Growth factors and signalling
molecules have the capacity to induce cellular proliferation and cellular differentiation. Addition of
transcription factors to a population of differentiated cells does not promise reprogramming of the potential
stem cells. Furthermore, ethical issues related with the development of embryonic stem cells (ESC’s) do not
apply to iPSCs, which offer a non-controversial strategy to create patient-specific stem cell lines. Hence the
present review article was aimed to briefly describe numerous oral mesenchymal stem cells (OMSC’s) and
role of Induced potential pluripotent stem cells (iPSCs) in the regenerative medicine and dentistry with a
focus on various iPSCs reprogramming techniques in the current scenario.

Author Biographies

Keerthi Narayan. V

Senior lecturer, Department of Oral Pathology and Microbiology

Vasumathi.D

Lecturer, Department of Public Health
Dentistry

Pavithra.D

Senior lecturer, Department of Oral Pathology and Microbiology

NirmalFamilaBettie

Associate Professor, Department of
Prosthodontics, Thai Moogambigai Dental College and Hospital, Dr. M. G. R. Educational and Research Institute,
Chennai

Published

2021-03-24

How to Cite

Keerthi Narayan. V, Vasumathi.D, Pavithra.D, & NirmalFamilaBettie. (2021). Potential Stem Cells of Oral Origin- A review on Induced Pluripotent Stem Cell Technology. Indian Journal of Forensic Medicine & Toxicology, 15(2), 228-233. https://doi.org/10.37506/ijfmt.v15i2.14312