Role of Omega 3 Fatty acids, Vitamin D, Vitamin B12, Vitamin B6 and Folate in Mental wellbeing- A Short review of Literature
Keywords:Mental health, Vitamin B12, Vitamin D, Omega 3 Fatty acids, Folate, Vitamin B6
Neuropsychiatric conditions have been linked to around 14 percent of the global disease burden, mainly
due to the chronically debilitating nature of depression and other widespread mental disorders, alcohol and
drug use disorders, and psychosis. The science and lay press have confirmed that vitamin D is an important
factor that can have major health benefits in the prevention and treatment of many chronic diseases. Most
people have inadequate vitamin D levels in this country. This is also relevant for people with depression and
other mental illnesses as well. Inadequate food consumption, lifestyle or other factors are a major causes of
Vitamin D deficiency. Successful diagnosis and treatment of insufficient levels of vitamin D in people with
depression and other mental illnesses could be a simple and cost-effective therapy that could enhance the
long-term health outcomes and quality of life of patients. It is now well known that omega-3 fatty acids are
important for physical health, and there is growing evidence that omega-3 fatty acids may also be important
for mental health. Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), the two major omega-3
fatty acids in fish oil, have essential biological roles within the CNS. DHA is a major structural component
of neuronal membranes, and modifying the neuronal membrane fatty acid composition contributes to
functional changes in the behaviour of phospholipid membrane-embedded receptors and other proteins.
EPA has major physiological roles that can influence the behaviour of neurons. For innumerable aspects
of brain functioning, adequate nutrition is needed. A modifiable risk factor for depression may be the poor
quality of diet. The goal was to evaluate and synthesize the existing understanding of the role of nutrition
in mental well-being. The risk of depression is increased by low omega-3 fatty acid status. Both fish oil and
folic acid supplements have been successfully used to treat depression. The response to antidepressants is
decreased by folate deficiency. Deficiencies in folate, vitamin B12, Vitamin D, Omega 3 fatty acids, Vitamin
B6 tend to be more prevalent in depressed individuals than in nondepressed individuals. In this short review
of Literature we have focused on role of Omega 3 Fatty acids, Vitamin D, Vitamin B12, Vitamin B6 and
Folate in Mental wellbeing.
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