Thyroid Profile and Its Correlation with Serum Creatinine in Chronic Kidney Disease Patients in Tertiary Care Hospital

Authors

  • Roshni G. Sadaria
  • Smita N. Vasava

DOI:

https://doi.org/10.37506/ijfmt.v15i2.14390

Keywords:

CKD, Serum Creatinine, Thyroid Hormones.

Abstract

Background: Chronic kidney disease (CKD) is defined as abnormalities in kidney structure or function
present for > 3 months and have other health implications. Thyroid hormones are important for electrolyte
homeostasis and also for the growth and development of the kidney. Study shows that hypothyroidism is
commonly seen in later stages of CKD. This study was conducted to investigate thyroid hormone profile and
its correlation with creatinine in CKD patients.
Materials and Methods: The present case control study was conducted at Dhiraj General Hospital, Piparia,
Vadodara, Gujarat, India in which 100 subjects were enrolled, out of which 50 were cases of CKD patients
and 50 were controls. The age group for the study was 18 to 70 years. Blood samples were drawn to measure
blood urea, serum creatinine, thyroid profile. Interpretation of data was done using Medcalc software.
Conclusion: Serum TSH levels were high in cases compared to controls but results were not significant.
Significant negative correlation was found between free thyroid hormones and serum creatinine. Correlation
of creatinine with T3, T4 and TSH were not significant. Subclinical hypothyroidism is found in our population
with undialyzed CKD. More studies involving large population size are required to ascertain these findings.

Author Biographies

Roshni G. Sadaria

Associate Professor

Smita N. Vasava

Assistant Professor, Department of Biochemistry, Smt. BK Shah Medical Institute &
Research Centre, Sumandeep Vidyapeeth (An Institute Deemed to be University), Piparia, Vadodara, Gujarat,
India

Published

2021-03-24

How to Cite

Roshni G. Sadaria, & Smita N. Vasava. (2021). Thyroid Profile and Its Correlation with Serum Creatinine in Chronic Kidney Disease Patients in Tertiary Care Hospital. Indian Journal of Forensic Medicine & Toxicology, 15(2), 681-685. https://doi.org/10.37506/ijfmt.v15i2.14390