Association of BMI with Serum Homocysteine in Polycystic Ovarian Syndrome Women
Keywords:BMI, Homocysteine, Lipid profile, PCOS.
Background: Women of reproductive age group are prone for Polycystic ovarian syndrome (PCOS). Recent
studies have shown that hyperhomocysteinemia is a risk factor for cardiovascular diseases. Prevalence of
cardiovascular disease and cardiovascular morbidities in women with PCOS are increased nowadays. The
purpose of the study is to assess correlation of BMI with serum homocysteine in PCOS females.
Materials and Methods: This is done on 50 PCOS patients and 50 voluntary age matched healthy women
with no menstrual abnormalities as controls. The age group for the cases and controls is 18-35 years. The
study was conducted at Biochemistry Department, SBKS MI & RC, Piparia, Vadodara, Gujarat, India.
Measurements of BMI and waist circumference were taken. Fasting blood samples were collected for
estimation of FBS, Lipid profile and homocysteine. Medcalc software was used for all statistical analysis. A
p-value less than 0.05 (p< 0.05) is considered as statistically significant.
Conclusion: Our study has shown significant higher levels of homocysteine in obese PCOS cases when
compared with non-obese PCOS cases. Also, significant higher level of homocysteine and triglyceride are
seen in PCOS cases compared to controls. Regular follow up for lipid profile and homocysteine is required
for PCOS patients to prevent CVS complications.
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