Haplotype Profiling of Y-STRs among Northern Population in Thailand
Keywords:Allele frequency, Forensic genetic, Haplotype frequency, Y-STRs
Background: The investigation of Y-short tandem repeats (Y-STRs) has been widely performed in forensic
caseworks. Due to variation between populations, understanding of genetic information within individual a
population could provide the database and scientifically reliable results. This study was to investigate allele
and haplotype frequencies of Y-STRs among localized people who lived in northern Thailand.
Methods: A retrospective descriptive study was conducted by gathering medical reports of Y-STRs typing.
The allele frequency and gene diversity as well as haplotype frequency and diversity were calculated.
Pairwise genetic distance (Rst) was also calculated based on haplotype pattern by using AMOVA and
Multidimensional Scaling (MDS) tools.
Results: The result showed that DYS389II, DYS439, and DYS392 represented the highest number of allele
patterns. The highest and lowest allele frequency was found to be allele 14 of DYS437 and allele 13 of
DYS437, respectively. The highest and lowest gene diversity was observed in DYS389II and DYS437,
respectively. One-hundred and sixty different haplotypes were defined where 144 carried a unique haplotype
and 16 carried a replicate haplotype. A significant Rst value was obtained between the studied population and
central Thai population.
Conclusion: This study provided genetic database of Y-STRs among localized population in northern region
of Thailand. The genetic structure of our subjects also represented the significant close relationship with
some other populations in Southeast Asia.
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