A Study on the Histopathological Changes in Cases of Pesticide Poisoning and Proposed Diagnostic Algorithm
Keywords:autopsy, histopathology, pesticide poisoning
Pesticide poisoning in developing world is a global public health problem. Incidences of poisoning are
increasing with socio-economic hurdles. Often reporting and chemical examination of samples collected
from viscera are difficult to precisely diagnose cases and therefore extensive studies on histopathological
corroborations of vital organs such as stomach, liver and kidney is necessary along with socio-demographic
data. The common autopsy findings were cyanosis in the lips, in the fingertips and nose. Histological
findings in stomach revealed congestion, erosion of muscularis mucosa, submucosal petechial haemorrhages
and necrosis. Liver shows congestion, sinusoidal dilution, degeneration of hepatocytes and haemorrhages.
Kidney shows tubular necrosis and glomerular congestion. However, history of poisoning along with
autopsy and histological findings are considered as strong evidence for acute organophosphorous poisoning
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