Hypolipidemic Effects of Rosa Damascena Mill. Extract in Streptozotocin-induced Diabetic Rats

Authors

  • Tamam Jauhar
  • Bilqis Inayatillah
  • Maftuchah Rochmanti
  • Achmad Basori

DOI:

https://doi.org/10.37506/ijfmt.v15i2.14461

Keywords:

Lipid profile, Rosa damascena, Streptozotocin

Abstract

Background: Diabetes mellitus is a chronic hyperglycemic condition with a lot of complication which can
lead to death. Vascular complication in diabetes commonly caused by dyslipidemia which characterized
by decreased HDL, elevated LDL, Cholesterol and Triglyceride. Rosa damascena- an ornamental plantthoughts to have anti-hyperglycemia and antioxidant effects because of its large amount of polyphenolic
components . This study analyzed hypolipidemic activity properties of an ethanol extract of Rosa damascena
by measuring the lipid profile using various doses. Methods: This research is experimental study with
randomized post-test only control group design. Twenty male Wistar rats divided into 5 groups; The groups
were Healthy Control Group (HCG), Diabetes Group (DG), and Extract Group: P1 (250 mg/kgBW), P2
(500 mg/kgBW), P3 (1000 mg/kgBW). All treatment groups were injected by single-dose streptozotocin
50 mg/kgBW to induce diabetes, and given the Rosa damascena ethanolic extract oral treatment for 2
weeks. Statistical results showed that Rosa damascena significantly decrease cholesterol (58.2±15.19), LDL
(11±2.44) optimally in dose 250 mg/KgBW and triglyceride (96.7±44.2) optimally in dose 500 mg/kgBW
after 14 days. Conclusion: Rosa damascena extract seems to be great candidate for anti-hyperlipidemic
drugs.

Author Biographies

Tamam Jauhar

Master program student in Basic Medical Science, Faculty of Medicine, Universitas Airlangga, Surabaya

Bilqis Inayatillah

Master program student in Basic Medical Science, Faculty of Medicine, Universitas Airlangga, Surabaya

Maftuchah Rochmanti

Lecturer, Department of Pharmacology, Faculty of Medicine, Universitas Airlangga, Surabaya

Achmad Basori

Professor,
Department of Pharmacology, Faculty of Medicine, Universitas Airlangga, Surabaya

Published

2021-03-24

How to Cite

Tamam Jauhar, Bilqis Inayatillah, Maftuchah Rochmanti, & Achmad Basori. (2021). Hypolipidemic Effects of Rosa Damascena Mill. Extract in Streptozotocin-induced Diabetic Rats. Indian Journal of Forensic Medicine & Toxicology, 15(2), 1065-1070. https://doi.org/10.37506/ijfmt.v15i2.14461