Molecular Co-Localization of Human Epstein Barr Virus Infection Associated with the Expressed Protein of Cyclin D1 \Cyclin Dependent Kinase 4 in Hodgkin’s Lymphoma Tissues
Keywords:EBV; Hodgkin’s lymphoma (HL), Cyclin D1;CDK4, CISH, IHC.
This retrospective case-control study to assess the impact of Cyclin D1 and CDK4 expression along with
EBV infection with Hodgkin’s lymphoma (HL).80 lymph node included in this study; (40) formalin-fixed,
paraffin- embedded biopsies from Hodgkin’s lymphoma (HL), and (40) apparently healthy lymph nodes as
control group. EBV detection was done by CISH whereas IHC detection system was used to evaluate both
Cyclin D1 & CDK4 gene expression.
The positive –EBERs CISH reactions detected in 16 / 40 (40 %) of Hodgkin lymphoma tissues while positive
- EBERs reactions detected in 3 out of 40 tissues (7.5%) in control lymph nodes tissues. Statistically was
found highly significant between study groups (P value = < 0.05). Cyclin D1 & CDK4 -IHC were detected
in 40% and 52.5% of HL, respectively. Statistically, significant differences noticed among negative, low and
moderate scoring of tissues (P<0.05).
Significant EBV gene expressions along with higher percentage of tissues in which Cyclin D1 & CDK4
genes being expressed may be indicator their possible role in the pathogenesis and / or the carcinogenesis of
a subset of our Hodgkin’s lymphoma cases.
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