Association between Genetic Polymorphism of ADH3 exon 8 and ADH2 exon 9 Genes and Specific Enzymes with Alcoholism
Keywords:Alcohol, ADH2- exon9, ADH3 exon 8, SGOT, SGPT and catalase.
A retrospective cohort study of the relationship between ADH2- exon9 and ADH3 exon 8 genes polymorphisms
with specific enzymes SGOT, SGPT, and catalase among Iraqi individuals identified with alcohol abuse
was conducted during period from December 2018 to June 2019. Blood samples of the research subjects
have extracted DNA. The genetic polymorphisms analyses were conducted by Restriction Fragment Length
Polymorphism (RFLP-PCR) for ADH2- exon9 and ADH3 exon 8 genes. The current study shows that the
presence of a catalase was significantly associated with genotype of ADH2- exon9 (AA, AC, CC) among
cases at (p < 0.05). Whereas the presence of an SGOT, SGPT and catalase were non significantly associated
with genotype of ADH3 exon 8 (AA, AG, GG) among cases at (p < 0.05), while SGPT was significantly
among control at (p < 0.05).
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