Association between Genetic Polymorphism of ADH3 exon 8 and ADH2 exon 9 Genes and Specific Enzymes with Alcoholism

Authors

  • Anwar A. Abdulla

DOI:

https://doi.org/10.37506/ijfmt.v15i2.14526

Keywords:

Alcohol, ADH2- exon9, ADH3 exon 8, SGOT, SGPT and catalase.

Abstract

A retrospective cohort study of the relationship between ADH2- exon9 and ADH3 exon 8 genes polymorphisms
with specific enzymes SGOT, SGPT, and catalase among Iraqi individuals identified with alcohol abuse
was conducted during period from December 2018 to June 2019. Blood samples of the research subjects
have extracted DNA. The genetic polymorphisms analyses were conducted by Restriction Fragment Length
Polymorphism (RFLP-PCR) for ADH2- exon9 and ADH3 exon 8 genes. The current study shows that the
presence of a catalase was significantly associated with genotype of ADH2- exon9 (AA, AC, CC) among
cases at (p < 0.05). Whereas the presence of an SGOT, SGPT and catalase were non significantly associated
with genotype of ADH3 exon 8 (AA, AG, GG) among cases at (p < 0.05), while SGPT was significantly
among control at (p < 0.05).

Author Biography

Anwar A. Abdulla

Assoc. Prof., Biology Dept. College of Science, University of Babylon, Iraq

Published

2021-03-24

How to Cite

Anwar A. Abdulla. (2021). Association between Genetic Polymorphism of ADH3 exon 8 and ADH2 exon 9 Genes and Specific Enzymes with Alcoholism . Indian Journal of Forensic Medicine & Toxicology, 15(2), 1320-1326. https://doi.org/10.37506/ijfmt.v15i2.14526