Effect of Litter Size Manipulation on the Reproductive Performance of BALB/C Mice

Authors

  • Laith Mahdi Muhammad
  • Aqeel Handil Al Jothery
  • Hikmat Sahib Nassir

DOI:

https://doi.org/10.37506/ijfmt.v15i2.14536

Keywords:

Litter size, reproductive efforts, manipulation of litters, lactation

Abstract

Many of previous studies on lactating animals with natural litters did not support the negative link between
litter size and pup mass; however, artificial manipulation of litters could be an option to support that. In
this study, we manipulated the litters of lactating BALB/C mice with having two groups. Enlarged litter SL
(LS=8; N=5) and reduced litters SS (LS=2; N=6) were used in this experiment and also 7 virgin female mice
were assigned for control group. Mother’s body mass and food intake were daily measured throughout the
experiment. Litter size, litter mass, pup mass, mortality rate of pups in the studied groups were also daily
measured throughout lactation. The lactating mice in both groups significantly ate more food intake compared
to non –reproducing mice. Mice with enlarged litters had significantly greater food intake compared to the
mice with reduced litters. Litter masses at weaning of SL mice were significantly higher compared to the
SS mice. However, pup mass at weaning was significantly lighter in SL mice compared to the pup mass in
the SS mice. Our present study concludes that the litter size of manipulated litters was negatively associated
with pup mass at weaning

Author Biographies

Laith Mahdi Muhammad

M.Sc., Department of Physiology and Pharmacology / College of Veterinary Medicine, University of Kerbala,
Iraq

Aqeel Handil Al Jothery

Assist. Prof., Department of Basic Sciences, College of Dentistry, University of Babylon/Iraq. Institute of
Biological and Environmental Sciences/University of Aberdeen/UK

Hikmat Sahib Nassir

Assist. Prof., Department of Public Health /
College of Veterinary Medicine, University of Kerbala, Iraq

Published

2021-03-24

How to Cite

Laith Mahdi Muhammad, Aqeel Handil Al Jothery, & Hikmat Sahib Nassir. (2021). Effect of Litter Size Manipulation on the Reproductive Performance of BALB/C Mice. Indian Journal of Forensic Medicine & Toxicology, 15(2), 1399-1407. https://doi.org/10.37506/ijfmt.v15i2.14536