Effectiveness of Giving Secang Wood Extract (Caesalpinia Sappan L) Against IL-6 And IL-10 Levels in Balb / C Mice With Vulvovaginalis Candidiasis

Authors

  • Sri Wahyu
  • Firdaus Hamid
  • Mochammad Hatta
  • Khairuddin Djawad
  • Agussalim Bukhari
  • Rosdiana Natzir
  • Alfina Baharuddin

DOI:

https://doi.org/10.37506/ijfmt.v15i2.14567

Keywords:

Secang wood, IL-6, IL-10, vulvovaginalis candidiasis

Abstract

The aim of this study was to test the effectiveness of secang wood extract (Caesalpinia sappan L) on
IL-6 and IL-10 expression in Balb / c mice with vulvovaginalis candidiasis. This type of research is an
experimental laboratory, with a control group design using experimental animals as research objects. The
research subjects were BALB / c mice weighing 35-40 grams, aged 10-12 weeks, the number of experimental
animals needed in this study was 18 for 3 random groups, each group being 6. Analysis and data processing
using the excel program SPSS Repeated ANOVA Test was used to measure differences in cytokine levels.
IL-6 levels in group 1 (control) where the value of IL-6 expression after infection (H1) was 4309.40 pg /mL
(IQR value 3803.8-4963.5) after treatment (H7) in the control group increased by 5578.12 pq / mL (IQR
5330.3 - 6162.9). In group 2 that were given fluconazole and secang wood extract, IL-6 levels tended to
decrease by 3516.4 pq / mL (IQR: 3070.4-4061.6) Secang wood after infection decreased from 3417.34 pq
/ mL to 2782.97 pq / mL after treatment. In Group 2 that was given fluconazole and secang wood extract,
IL-10 levels increased by 1414.8 pq / ml (IQR: 1061.7- 3158) after infection, to 3268.35 pq / ml (IQR
value: 1789.9-3709.6) after treatment. given secang wood after infection increased from 2032.67 pq / ml to
3091.83 pq / mL after treatment. The p value is 0.008. Obtained the effect of secang wood extract in reducing
levels of Interleukin 6 and can increase the value of IL-10 levels after administration of secang wood extract
on candidiasis vulvovaginalis

Author Biographies

Sri Wahyu

Research in Postgraduate Program, Faculty of Medicine , Hasanuddin University, Indonesia

Firdaus Hamid

Lecturer
Departement of Microbiology Faculty of Medicine, Hasanuddin University, , Indonesia

Mochammad Hatta

Professor Department
of Microbiology, Faculty of Medicine, Hasanuddin University, Indonesia

Khairuddin Djawad

Lecturer Department Of
Dermatovenerology Faculty of Medicine, Hasanuddin University, Indonesia

Agussalim Bukhari

Lecturer Department of Nutrition
Faculty of Medicine, Hasanuddin University Indonesia

Rosdiana Natzir

Professor Department of Microbiology, Faculty of
Medicine, Hasanuddin University, Indonesia

Alfina Baharuddin

Lecturer Department of Environmental Faculty of Public Health,
University Muslim of Indonesia

Published

2021-03-24

How to Cite

Sri Wahyu, Firdaus Hamid, Mochammad Hatta, Khairuddin Djawad, Agussalim Bukhari, Rosdiana Natzir, & Alfina Baharuddin. (2021). Effectiveness of Giving Secang Wood Extract (Caesalpinia Sappan L) Against IL-6 And IL-10 Levels in Balb / C Mice With Vulvovaginalis Candidiasis. Indian Journal of Forensic Medicine & Toxicology, 15(2), 1609-1614. https://doi.org/10.37506/ijfmt.v15i2.14567

Most read articles by the same author(s)