Evaluation of Lipocalin-2 and Visfatin, and Vitamin (D,C, and E) in Serum of Diabetic Patients with Chronic Periodontitis

Authors

  • Anas Qahtan Hamdi
  • Entedhar R. Sarhat
  • Nagham Hasan Ali
  • Thuraia Rifaat Sarhat

DOI:

https://doi.org/10.37506/ijfmt.v15i2.14578

Keywords:

Type2 diabetes; Visfatin; Lipocalin-2;Serum.

Abstract

Objective: The aim of the present study is to verify the hypothesis that salivary and serum lipocalin-2
and visfatin, and vitamin (D,C, and E) used as indicators for chronic periodontitis among DMT2 patients.
Subjects and methods: We enrolled 41 type 2 diabetic patients with chronic periodontitis -18 males and 23
females, aged 60± 14 years and 49 controls- 26 males and 23 females, aged 61.8 ± 12.5 years. Blood samples
were collected after an overnight fast and routine biochemical parameters such as glucose, lipocalin-2 and
visfatin, and vitamin (D,C, and E)were determined in all samples. Data were considered significant at a level
of p < 0.05.Periodontitis status was established using classic clinical parameters, Plaque index (PI), gingival
index (GI), probing depth (PD) and clinical attachment level (CAL). Results: 1) The mean serum of blood
glucose, Visfatin, and LCN2 were higher in patients group than in those with normal control group (P<0.001
for all comparisons) ; 2) patients with had a lower Vitamin D,C, and E than those with a normal group (P <
0.001 for all comparisons).Conclusions: The activity of lipocalin-2 and visfatin in saliva and serum can be
useful in diagnosis, monitorization and treatment of this disease. Further studies are needed to elucidate the
role of lipocalin-2 and visfatin in periodontitis and systemic disease interactions.

Author Biographies

Anas Qahtan Hamdi

Lec. Clinical Biochemistry, University of Tikrit

Entedhar R. Sarhat

Prof. Orthodontic Department, College of Dentistry, University
of Tikrit

Nagham Hasan Ali

Lec. Clinical Biochemistry, University of Tikrit

Thuraia Rifaat Sarhat

B.Sc., College of Education, University of Baghdad

Published

2021-03-24

How to Cite

Anas Qahtan Hamdi, Entedhar R. Sarhat, Nagham Hasan Ali, & Thuraia Rifaat Sarhat. (2021). Evaluation of Lipocalin-2 and Visfatin, and Vitamin (D,C, and E) in Serum of Diabetic Patients with Chronic Periodontitis. Indian Journal of Forensic Medicine & Toxicology, 15(2), 1668-1674. https://doi.org/10.37506/ijfmt.v15i2.14578