Recent Advances of Therapeutic Strategies Based on the Molecular Signature in Non-Syndromic Congenital Neutropenia

Authors

  • Mohammad Darvish
  • Mohammadreza Nazer
  • Hamzeh Shahali
  • Ebrahim Karimi
  • Alireza Dadashi
  • Seyed Zia Hejripour
  • Majid Noori

DOI:

https://doi.org/10.37506/ijfmt.v15i2.14588

Keywords:

Neutropenia, Molecular mechanisms, Therapeutic strategies, Mutations

Abstract

Neutropenia has been defined to be classified into transient and chronic forms based upon duration and
acquired or congenital forms. Chronic neutropenia is considered as congenital, cyclic, autoimmune and
idiopathic categorizes, where congenital and cyclic categories are hereditary forms of neutropenia, but the
idiopathic and autoimmune are known as acquired neutropenia. In the present review, we focus highly on
the genetic subtypes of non-syndromic congenital neutropenia and therapeutic strategies regarding to recent
evidence. All aspects of molecular pathogenesis and biology have not been clarified so far; therefore, further
in-depth understanding of the molecular mechanisms is needed to reveal roles of molecular mechanisms,
and pathways involved in the development of congenital neutropenia and to provide a basis for achieving
novel therapeutic strategies.

Author Biographies

Mohammad Darvish

Assistant Professor, Infectious Diseases and Tropical Medicine Research Center (IDTMRC), Department of
Aerospace and Subaquatic Medicine, AJA University of Medical Sciences, Tehran, Iran

Mohammadreza Nazer

Professor, Department
of Infectious Diseases, Hepatitis Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran

Hamzeh Shahali

Assistant Professor, Department of Aerospace and Subaquatic Medicine, AJA University of Medical Sciences,
Tehran, Iran

Ebrahim Karimi

Assistant Professor, Department of Emergency Medicine, Be-sat Hospital, AJA University of
Medical Sciences, Tehran, Iran

Alireza Dadashi

Assistant Professor, Department of Emergency Medicine, Be-sat Hospital, AJA University of
Medical Sciences, Tehran, Iran

Seyed Zia Hejripour

Assistant Professor, Department of Emergency Medicine, Be-sat Hospital, AJA University of
Medical Sciences, Tehran, Iran

Majid Noori

Assistant Professor, Infectious Diseases and Tropical Medicine Research Center (IDTMRC), Department of
Aerospace and Subaquatic Medicine, AJA University of Medical Sciences, Tehran, Iran

Published

2021-03-24

How to Cite

Mohammad Darvish, Mohammadreza Nazer, Hamzeh Shahali, Ebrahim Karimi, Alireza Dadashi, Seyed Zia Hejripour, & Majid Noori. (2021). Recent Advances of Therapeutic Strategies Based on the Molecular Signature in Non-Syndromic Congenital Neutropenia. Indian Journal of Forensic Medicine & Toxicology, 15(2), 1727-1735. https://doi.org/10.37506/ijfmt.v15i2.14588