Clinical Characteristics of Coronavirus Disease 2019 in a Cohort of Iranian Patients: Olfactory Dysfunction as a Frequent Clinical Presentation

Authors

  • Alireza Kamali
  • Mehrnoosh Ebadi
  • Hassan Vahidnezhad
  • Alireza Mohammadi
  • Mohsen Dalvandi

DOI:

https://doi.org/10.37506/ijfmt.v15i2.14594

Keywords:

COVID-19, Iran, SARS-CoV-2, Olfactory dysfunction;

Abstract

Background: Since its outbreak, the 2019 novel coronavirus (SARS-CoV-2) has been associated with
coronavirus disease 2019 (COVID-19). The full spectrum of disease severity of COVID-19 is still unknown.
In this study which is the first report from Iran, we showed that olfactory dysfunction is a frequent clinical
manifestation among COVID-19 patients.
Methods: All patients with suspected SARS-CoV-2 infection were admitted to Arak hospitals in Iran. We
retrospectively collected and analyzed data on patients with either laboratory-confirmed SARS-CoV-2
infection by real-time RT-PCR and/or chest CT
Results: Most patients in our cohort had mild COVID-19 (104 [60.4%] of 172) . Common symptoms at
the onset of disease included (subjective) fever (131 [76%] of 172 patients), cough (130 [75.5%]), myalgia
(107 [62%]) dyspnea (92 [53.5%]), chills (96 [55.8%]), and headache (94 [54.6%]). Olfactory dysfunction
(OD), including anosmia, hyposmia, hyperosmia, and dysosmia, were reported by 61 ([36.5%] of 167)
patients. The most common concurrent symptoms beside the olfactory dysfunctions, were fever (39 [69.6%]
of 56 patients) and chills (26 [46.4%]), respectively. For the most part, the patient’s condition worsened
after the notice of anosmia/dysgeusia (48 [85.7%] of 56 patients). The majority of anosmic patients were
recovered from COVID-19 (50 [89.3%] of 56 patients). The anosmia/dysgeusia was resolved in 42 [75%]
of 56 patients after two weeks.
Conclusion: Taken together, this study reports the disease spectrum of SARS-CoV-2 infection in a cohort of
172 Iranian adult patients. To the best of our knowledge, this is the first report from Iran.

Author Biographies

Alireza Kamali

Associate Professor, Department of Anesthesiology and Critical Care, Arak University of Medical Sciences,
Arak, Iran

Mehrnoosh Ebadi

General Practitioner, Research Deputy Expert, Department of Anesthesiology and Critical Care,
Arak University of Medical Sciences, Arak, Iran

Hassan Vahidnezhad

Associate Professor, Molecular Medicine Department, Pasteur
Institute of Iran, Tehran, Iran,  Associate Professor, Jefferson Institute of Molecular Medicine, Sidney Kimmel
Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania, USA

Alireza Mohammadi

Assistant Professor, Department
of Neurosurgery, Arak University of Medical Sciences, Arak, Iran

Mohsen Dalvandi

Assistant Professor, Department
of Neurosurgery, Arak University of Medical Sciences, Arak, Iran

Published

2021-03-24

How to Cite

Alireza Kamali, Mehrnoosh Ebadi, Hassan Vahidnezhad, Alireza Mohammadi, & Mohsen Dalvandi. (2021). Clinical Characteristics of Coronavirus Disease 2019 in a Cohort of Iranian Patients: Olfactory Dysfunction as a Frequent Clinical Presentation. Indian Journal of Forensic Medicine & Toxicology, 15(2), 1768-1770. https://doi.org/10.37506/ijfmt.v15i2.14594