The Effect of Artemisia Dracunculus L. on Mitotic Index in Bone Marrow and Spleen Cells of Mice: In Vivo Study

Authors

  • Ahmed Hamed Jwaid
  • Ali Faris Hassan
  • Ali Abdulhussain Kasim

DOI:

https://doi.org/10.37506/ijfmt.v15i2.14617

Keywords:

Artemisia dracunculus, bone marrow cells, methotrexate, mitotic index spleen cells

Abstract

Artemisia dracunculus L. (tarragon) is a rich source of herbal remedies with antioxidant and anti-inflammatory
properties. In the present study, the proliferation of bone marrow and spleen cells of mice was evaluated after
extraction of Artemisia dracunculus with 80% of ethanol. Two doses of the extract (500mg/kg body weight
and 1000mg/kg body weight) were given to the mice for seven successive days. On day eight, mice were
sacrificed and cells from bone marrow and spleen were collected; mitotic index was calculated and results
were compared with that of methotrexate at a dose 20mg/kg body weight ( positive control ) and distilled
water ( negative control). The results showed that the dose 500mg/kg body weight of Artemisia dracunculus
extract caused significant increase in mitotic index in both bone marrow and spleen cells of mice when
compared with negative control. While, the dose 1000mg/kg body weight of Artemisia dracunculus extract
caused significant decrease in mitotic index in both bone marrow and spleen cells of mice when compared
with negative control.

Author Biographies

Ahmed Hamed Jwaid

Lecturer, Department of Pharmacology and Toxicology, College of Pharmacy, University of Baghdad; BaghdadIraq

Ali Faris Hassan

Lecturer, Department of Pharmacology and Toxicology, College of Pharmacy, University of Baghdad; BaghdadIraq

Ali Abdulhussain Kasim

Lecturer Department of Clinical Laboratory Sciences, College of Pharmacy, University of Baghdad;
Baghdad-Iraq

Published

2021-03-24

How to Cite

Ahmed Hamed Jwaid, Ali Faris Hassan, & Ali Abdulhussain Kasim. (2021). The Effect of Artemisia Dracunculus L. on Mitotic Index in Bone Marrow and Spleen Cells of Mice: In Vivo Study. Indian Journal of Forensic Medicine & Toxicology, 15(2), 1879-1883. https://doi.org/10.37506/ijfmt.v15i2.14617