The Effect of Artemisia Dracunculus L. on Mitotic Index in Bone Marrow and Spleen Cells of Mice: In Vivo Study
Keywords:Artemisia dracunculus, bone marrow cells, methotrexate, mitotic index spleen cells
Artemisia dracunculus L. (tarragon) is a rich source of herbal remedies with antioxidant and anti-inflammatory
properties. In the present study, the proliferation of bone marrow and spleen cells of mice was evaluated after
extraction of Artemisia dracunculus with 80% of ethanol. Two doses of the extract (500mg/kg body weight
and 1000mg/kg body weight) were given to the mice for seven successive days. On day eight, mice were
sacrificed and cells from bone marrow and spleen were collected; mitotic index was calculated and results
were compared with that of methotrexate at a dose 20mg/kg body weight ( positive control ) and distilled
water ( negative control). The results showed that the dose 500mg/kg body weight of Artemisia dracunculus
extract caused significant increase in mitotic index in both bone marrow and spleen cells of mice when
compared with negative control. While, the dose 1000mg/kg body weight of Artemisia dracunculus extract
caused significant decrease in mitotic index in both bone marrow and spleen cells of mice when compared
with negative control.
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