GPx1-rs1050450 Gene Polymorphism Association with End Stage Renal Disease in Type2 Diabetic Patients of Babylon Province/Iraq
Keywords:Diabetes mellitus, Oxidative stress, ESRD, GPx1 gene polymorphism
Background: Glutathione Peroxidase-1 is an antioxidant enzyme, play an important role in defense against
oxidative stress. In Pro198Leu (C/T) polymorphism of Glutathione gene variation which result in lowering
enzyme activity increasing microvascular complications of diabetic patients. Aim: This study was aimed to
estimate the relationship between GPX1 gene variation and the risk of develop and progression of end stage
renal disease in type I diabetic nephropathy patients. In this study, it has been examined 140 type I diabetes
mellitus patients with nephropathy and 40 healthy control. Results: All samples have been genotyped by
using polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) techniques.
In diabetic nephropathy patients, there were a significant elevation in in the variation (TT) genotype and (T)
allele frequencies compared with control group.
Conclusions: Using major Iraqi diabetic patients of Babylon province we studied the transforming effect of
GPX1 gene polymorphism on the risk of development diabetic nephropathy, this study was found that the
(TT) genotype of GPX1 SNPs increases the risk of development diabetic nephropathy, while (CC) genotype
decreases the chance for developing disease. These results will gave the way for better perception of the
genetic influencing on the development and progression of diabetic nephropathy.
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