Profile of Determinant Factors on Drug Allergy Severity in Indonesian Children at Dr. Soetomo General Academic Hospital, Surabaya, Indonesia

Abstract

Background: Drug allergy in children is a rare case that needs special attention. Identifying the factors
that affect the severity of drug allergy is important for the improvement of drug allergy management in
Indonesian children. Objective: to analyze the factors that influence drug allergy severity in Indonesian
children. Methods: This study used a retrospective design and consecutive sampling in 2014-2018. The data
collected included sex, types of allergy-causing drugs, previous allergy history, parental allergy history, and
clinical manifestations. The data were analyzed by using a logistic regression test where the statistical test
results were significant if p <0.05. Results: The average age of the participants was 93.00 ± 50.54 months
with a median value of 84 (12 - 204) months. Drug allergy severity in children is influenced by several
things, such as the type of drug (? = 5.76; 95% CI 1.29 - 25.70; p = 0.022), sex (? = 1.27; 95% CI 0.30 - 5.36;
p = 0.743), previous allergy history (? = 2.44; 95% CI 0.10 - 58.67; p = 0.583), and a drug allergy history on
parents (? = 0.65; 95% CI 0.06 - 6.75; p = 0.719). Conclusion: There is a significant relationship between
drug allergy severity and the type of drug whereas sex, previous allergy history, and a history of allergy on
parents do not find a significant connection.