Relationship between Blood group and Chronic Myeloid Leukemia with the Role of the Oxidative Stress
Keywords:ABO Blood Groups, Chronic myeloid leukemia, Oxidative stress
Chronic myeloid leukemia characterized by the expansion of a clone of hematopoietic cells that carries
the Philadelphia chromosome (Ph). The aim of study are to find if there is an association between blood
groups and chronic myeloid leukemia, and to determine the role of the oxidative stress as risk factor. Ninety
persons included in the study (45 as patient and 45 as control group). Patients were suffering from CML,
the control are free from this disease. There are ranged from (21-60) years old where they are divided in
to four group according to blood group (A, B, AB, and O). The sera were collected from the 90 persons
and analyzed by using enzyme linked immunosorbent assay (ELISA) for MDA and GSH. The results of
the study show that blood group O (44%) predominates in CML patients group followed by blood group A
(22%), B (18 %) and AB (16%). The mean serum level MDA value shows highly significance at (P?0.001)
change in the patients group in comparison with control. Also show that the level of MDA in male (900. 99
± 603.89) is significantly higher than in female (582.28 ± 562.29). The mean serum level of GSH show that
significant decrease at (P?0.05) in patients group (40. 12 ± 27.33) than in control groups (55.20 ± 28.79). As
a conclusion from this study, the importance of MDA and GSH in CML patients can be used to detect the
complications related to the among these patients.
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