Hypoglycemic Effects of Rosa damascena Mill. Ethanolic Extract on Blood Glucose Levels and Diameter of Langerhans Pancreatic Islets

Authors

  • Bilqis Inayatillah
  • Tamam Jauhar
  • Gondo Mastutik
  • Alphania Rahniayu

DOI:

https://doi.org/10.37506/ijfmt.v15i2.14679

Keywords:

hyperglycemic, Rosa damascena, Langerhans islets.

Abstract

Background: Diabetes mellitus is a chronic disorder caused by elevated levels of high blood glucose
(hyperglycemia). This chronic hyperglycemia causes ROS to accumulate and oxidative stress to increase.
Rosa damascena is a plant that contains high levels of antioxidants and polyphenols, but this is not widely
known to the public. Purpose: The aim of this study is to understand the hypoglycemic effects from Rosa
damascena on blood glucose levels and diameter of Langerhans pancreatic islets. Method: Thirty Wistar
albino rats (200-225gr) were divided into 6 groups. Group 1 was a normal control (KN), group 2 was
hyperglycemic (KD), group 3 was metformin 250 mg/kg BW (KM), group 4 was treatment extract 250 mg/
kg BW (P1), group 5 was treatment extract 500 mg/kg BW (P2) group 6 was treatment extract 1000 mg/
kg BW (P3). All animals in the group were injected with STZ 50 mg/kg BW, except for group 1. Result:
Data were analyzed statistically using SPSS- 22 software with the Kruskall-Wallis test (p<0.05). The result
showed that ethanolic extract of Rosa damascena has decreased blood glucose levels in days-14 (382
±21,97) with 250 mg/kg BW (P1) compare with another treatment group. In histological observed there are
no significant different between group (p>0.05). This is showing that ethanolic extract of Rosa damascena
has inability to repaired the diameter of Langerhans pancreatic islets. Conclusion: Ethanolic extract of Rosa
damascena decreased blood glucose levels but did not repaired the diameter of Langerhans pancreatic islets.

Author Biographies

Bilqis Inayatillah

Master Programs in Medical Basic of Science, Department of Anatomical Pathology, Faculty of Medicine,
Universitas Airlangga, Surabaya

Tamam Jauhar

Master Programs in Medical Basic of Science, Department of Anatomical Pathology, Faculty of Medicine,
Universitas Airlangga, Surabaya

Gondo Mastutik

Associate Professor of Department of Anatomical Pathology, Faculty
of Medicine, Universitas Airlangga, Surabaya

Alphania Rahniayu

Pathologist of Dr. Soetomo Hospital, Faculty of Medicine,
Universitas Airlangga, Surabaya

Published

2021-03-24

How to Cite

Bilqis Inayatillah, Tamam Jauhar, Gondo Mastutik, & Alphania Rahniayu. (2021). Hypoglycemic Effects of Rosa damascena Mill. Ethanolic Extract on Blood Glucose Levels and Diameter of Langerhans Pancreatic Islets. Indian Journal of Forensic Medicine & Toxicology, 15(2), 2133-2141. https://doi.org/10.37506/ijfmt.v15i2.14679