The efficacy of fractional erbium:YAG laser (2940 nm) compared to Microneedling of topical amniotic membrane stem cell conditioned medium (AMSC-CM) for photoaging

Authors

  • Cita Rosita Sigit Prakoeswa
  • Riyana Noor Oktaviyanti
  • Wisnu Triadi Nugroho
  • Febrina D Pratiwi
  • Luh Mas Rusyati
  • I G A A Praharsini
  • I G A A Elis Indira

DOI:

https://doi.org/10.37506/ijfmt.v15i2.14694

Keywords:

fractional laser, microneedling, photoaging,

Abstract

Background: Photoaging is a complex biologic process that affects various layers of the skin. Amniotic
membrane stem cell conditioned medium (AMSC-CM) that contain growth factors and have capability to
improve clinical picture of photoaged skin. Microneedling and laser devices are transdermal drug delivery
methods which shows promising results to improve photoaging .
Objective: To investigate the efficacy of topical AMSC-CM after YAG erbium fractional laser compare to
microneedling in photoaging.
Method :A clinical study, 60 adult women with photoaging. Randomized into two groups A 30 women
received AMSC-CM after fractional erbium:YAG laser (2940nm) and group B 30 woman received AMSCCM after microneedling. Both groups received the treatment 3 times with 2 weeks interval. The improvement
of pore, wrinkle, and UV spot as was evaluate before, after and post treatment using computer-stimulated
photograph skin analyzer.
Result: The evaluation of pore and UV spot showed greater improvement in the group of AMSC-CM with
fractional erbium:YAG laser compare to AMSC-CM with microneedling group (pore p:0,00 and UV spot
p:0,00). There was no significant different (p 0.43) of wrinkle improvement between both groups.
Conclusion: The combination of AMSC-CM and fractional erbium:YAG laser have better efficacy in the
improvement in photoaged skins.

Author Biographies

Cita Rosita Sigit Prakoeswa

Professor, Department of Dermatology and Venereology, Faculty of Medicine, Universitas Airlangga / Dr.
Soetomo General Academic Hospital, Surabaya, Indonesia

Riyana Noor Oktaviyanti

Researcher, Department of Dermatology and
Venereology, Faculty of Medicine, Universitas Airlangga / Dr. Soetomo General Academic Hospital, Surabaya,
Indonesia

Wisnu Triadi Nugroho

Researcher, Department of Dermatology and
Venereology, Faculty of Medicine, Universitas Airlangga / Dr. Soetomo General Academic Hospital, Surabaya,
Indonesia

Febrina D Pratiwi

Researcher, Department of Dermatology and
Venereology, Faculty of Medicine, Universitas Airlangga / Dr. Soetomo General Academic Hospital, Surabaya,
Indonesia,

Luh Mas Rusyati

Researcher, Departement of Dermatology and Venereology, Faculty of Medicine, Universitas Udayana
– Sanglah General Hospital, Bali, Indonesia

I G A A Praharsini

Researcher, Departement of Dermatology and Venereology, Faculty of Medicine, Universitas Udayana
– Sanglah General Hospital, Bali, Indonesia

I G A A Elis Indira

Researcher, Departement of Dermatology and Venereology, Faculty of Medicine, Universitas Udayana
– Sanglah General Hospital, Bali, Indonesia

Published

2021-03-24

How to Cite

Cita Rosita Sigit Prakoeswa, Riyana Noor Oktaviyanti, Wisnu Triadi Nugroho, Febrina D Pratiwi, Luh Mas Rusyati, I G A A Praharsini, & I G A A Elis Indira. (2021). The efficacy of fractional erbium:YAG laser (2940 nm) compared to Microneedling of topical amniotic membrane stem cell conditioned medium (AMSC-CM) for photoaging . Indian Journal of Forensic Medicine & Toxicology, 15(2), 2161-2167. https://doi.org/10.37506/ijfmt.v15i2.14694

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