The efficacy of fractional erbium:YAG laser (2940 nm) compared to Microneedling of topical amniotic membrane stem cell conditioned medium (AMSC-CM) for photoaging
Keywords:fractional laser, microneedling, photoaging,
Background: Photoaging is a complex biologic process that affects various layers of the skin. Amniotic
membrane stem cell conditioned medium (AMSC-CM) that contain growth factors and have capability to
improve clinical picture of photoaged skin. Microneedling and laser devices are transdermal drug delivery
methods which shows promising results to improve photoaging .
Objective: To investigate the efficacy of topical AMSC-CM after YAG erbium fractional laser compare to
microneedling in photoaging.
Method :A clinical study, 60 adult women with photoaging. Randomized into two groups A 30 women
received AMSC-CM after fractional erbium:YAG laser (2940nm) and group B 30 woman received AMSCCM after microneedling. Both groups received the treatment 3 times with 2 weeks interval. The improvement
of pore, wrinkle, and UV spot as was evaluate before, after and post treatment using computer-stimulated
photograph skin analyzer.
Result: The evaluation of pore and UV spot showed greater improvement in the group of AMSC-CM with
fractional erbium:YAG laser compare to AMSC-CM with microneedling group (pore p:0,00 and UV spot
p:0,00). There was no significant different (p 0.43) of wrinkle improvement between both groups.
Conclusion: The combination of AMSC-CM and fractional erbium:YAG laser have better efficacy in the
improvement in photoaged skins.
How to Cite
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Re use and mixing of content policy- We follow Creative Commons Licence Policy. We follow CC BY. Please refer below for all details
This license lets others distribute, remix, adapt, and build upon our work, even commercially, as long as they credit us for the original creation.
- The journal allows readers to read, download, copy, distribute, print, search, or link to the full texts of its articles and allow readers to use them for any other lawful purpose.
- The journal allows the author(s) to hold the copyright without restrictions.
- The journal allows the author(s) to retain publishing rights without restrictions