The Effect of Amniotic Membrane Stem Cell Metabolite Product (AMSP-MP) Combine with Vitamin E after Microneedling in Photoaging Progress

Authors

  • Cita Rosita Sigit Prakoeswa
  • Agatha Anindhita Ayu Ardhaninggar
  • Riyana Noor Oktaviyanti
  • Irmadita Citrashanty
  • Maylita Sari
  • Menul Ayu Umborowati
  • Dwi Murtiastutik

DOI:

https://doi.org/10.37506/ijfmt.v15i2.14695

Keywords:

vitamin E, microneedling, photoaging.

Abstract

Introduction: The photoaging is a cumulative process. Amniotic Membrane Stem Cell Metabolite Products
(AMSC-MP) that contain cytokines and growth factors that have a role in the skin’s rejuvenation process.
Vitamin E is an antioxidant that has a photoprotective effect. Topical combination of AMSC-MP and Vitamin
E are expected to have an effect on clinical photoaging improvement.
Objective: To evaluate the effect of topical combination of AMSC-MP with vitamin E after microneedling
compared with AMSC metabolite products after microneedling.
Methods: A total 60 photoaging women were included in this experimental analytic, controlled, matching
research. Each participant’s face was allocated to topical combination of AMSC-MP and vitamin E in
intervention group and AMSC-MP only in control group. Microneedling modality was use to enhance
epidermal penetration. Three treatment sessions were repeated at two weeks’ interval.
Results: From the comparison of the two groups showed there were significant different of mean value in
wrinkle, skin tone and UV spots with p-value < 0,005 in the intervention grup. While pore and polarized spot
do not show significant differences between two groups.
Conclusion: The administration of a topical combination of MP-AMSC and vitamin E after microneedling
provides clinical improvement in photoaging.

Author Biographies

Cita Rosita Sigit Prakoeswa

Professor, Department of Dermatology and Venereology, Faculty of Medicine, Universitas Airlangga / Dr.
Soetomo General Academic Hospital, Surabaya, Indonesia

Agatha Anindhita Ayu Ardhaninggar

Researcher, Department of Dermatology and
Venereology, Faculty of Medicine, Universitas Airlangga / Dr. Soetomo General Academic Hospital, Surabaya,
Indonesia

Riyana Noor Oktaviyanti

Researcher, Department of Dermatology and
Venereology, Faculty of Medicine, Universitas Airlangga / Dr. Soetomo General Academic Hospital, Surabaya,
Indonesia

Irmadita Citrashanty

Researcher, Department of Dermatology and
Venereology, Faculty of Medicine, Universitas Airlangga / Dr. Soetomo General Academic Hospital, Surabaya,
Indonesia

Maylita Sari

Researcher, Department of Dermatology and
Venereology, Faculty of Medicine, Universitas Airlangga / Dr. Soetomo General Academic Hospital, Surabaya,
Indonesia

Menul Ayu Umborowati

Researcher, Department of Dermatology and
Venereology, Faculty of Medicine, Universitas Airlangga / Dr. Soetomo General Academic Hospital, Surabaya,
Indonesia

Dwi Murtiastutik

Researcher, Department of Dermatology and
Venereology, Faculty of Medicine, Universitas Airlangga / Dr. Soetomo General Academic Hospital, Surabaya,
Indonesia

Published

2021-03-24

How to Cite

Cita Rosita Sigit Prakoeswa, Agatha Anindhita Ayu Ardhaninggar, Riyana Noor Oktaviyanti, Irmadita Citrashanty, Maylita Sari, Menul Ayu Umborowati, & Dwi Murtiastutik. (2021). The Effect of Amniotic Membrane Stem Cell Metabolite Product (AMSP-MP) Combine with Vitamin E after Microneedling in Photoaging Progress . Indian Journal of Forensic Medicine & Toxicology, 15(2), 2168-2173. https://doi.org/10.37506/ijfmt.v15i2.14695

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