The Effect of Amniotic Membrane Stem Cell Metabolite Product (AMSP-MP) Combine with Vitamin E after Microneedling in Photoaging Progress

Abstract

Introduction: The photoaging is a cumulative process. Amniotic Membrane Stem Cell Metabolite Products
(AMSC-MP) that contain cytokines and growth factors that have a role in the skin’s rejuvenation process.
Vitamin E is an antioxidant that has a photoprotective effect. Topical combination of AMSC-MP and Vitamin
E are expected to have an effect on clinical photoaging improvement.
Objective: To evaluate the effect of topical combination of AMSC-MP with vitamin E after microneedling
compared with AMSC metabolite products after microneedling.
Methods: A total 60 photoaging women were included in this experimental analytic, controlled, matching
research. Each participant’s face was allocated to topical combination of AMSC-MP and vitamin E in
intervention group and AMSC-MP only in control group. Microneedling modality was use to enhance
epidermal penetration. Three treatment sessions were repeated at two weeks’ interval.
Results: From the comparison of the two groups showed there were significant different of mean value in
wrinkle, skin tone and UV spots with p-value < 0,005 in the intervention grup. While pore and polarized spot
do not show significant differences between two groups.
Conclusion: The administration of a topical combination of MP-AMSC and vitamin E after microneedling
provides clinical improvement in photoaging.