The Effects of Turmeric Extract (Curcuma longa) Loaded Hidrogels in Accelerating Wound Closure

Authors

  • David Setyo Budi
  • Reny I`tishom
  • Alphania Rahniayu
  • Mohammad Fathul Qorib

DOI:

https://doi.org/10.37506/ijfmt.v15i2.14699

Keywords:

Carboxymethyl Chitosan, Curcumin, Hydrogels, Turmeric, Wound Healing

Abstract

Background: Disruption to healing process results on longer healing duration from the timeline. Povidone
iodine and tulle are common management in wound care. The advance of industry in health sector and
the availability of natural ingredients in Indonesia provide opportunities for developing alternatives for
wound care. Turmeric (Curcuma longa) contains curcumin which is anti-inflammatory, antibacterial,
and antioxidant; it is good for wound healing. Hydrogel nanocomplexes of carboxymethyl chitosan can
maintain moisture in wound area and protect curcumin from hydrolysis. Objective: To analyze the potential
of turmeric extract loaded hidrogels in accelerating wound closur. Method: experimental research with
“post-test only control group design”. The sample consisted of 30 mice which were assigned into 5 groups.
Result: All experimental groups experienced a gradual decrease in wound length. The statistical test results
for groups II and III showed significant advantages compared to group IV (p<0.05). Meanwhile, group I
did not have significant differences in wound closure compared to group IV on day 1 and 3 (p>0.05), but it
had significant results (p<0.05) on day 5. Conclusion: Turmeric extract loaded hidrogels can accelerate the
reduction of wound length.

Author Biographies

David Setyo Budi

Student, Faculty of Medicine, Universitas Airlangga, Surabaya, 60131, Indonesia

Reny I`tishom

Lecturer, Department of
Medical Biology, Faculty of Medicine, Universitas Airlangga, Surabaya, 60131, Indonesia

Alphania Rahniayu

Lecturer, Department
of Anatomical Pathology, Faculty of Medicine, Universitas Airlangga, Surabaya, 60131, Indonesia

Mohammad Fathul Qorib

Lecturer,
Department of Pharmacology, Faculty of Medicine, Universitas Airlangga, Surabaya, 60131, Indonesia

Published

2021-03-24

How to Cite

David Setyo Budi, Reny I`tishom, Alphania Rahniayu, & Mohammad Fathul Qorib. (2021). The Effects of Turmeric Extract (Curcuma longa) Loaded Hidrogels in Accelerating Wound Closure . Indian Journal of Forensic Medicine & Toxicology, 15(2), 2201-2206. https://doi.org/10.37506/ijfmt.v15i2.14699