Effect of Photoprotective Cream of Mangosteen Pericarp Extract (Garcinia Mongostana L) Against 8-OHdG After UVB Exposure On Albino Mice

Authors

  • Dian Amelia Abdi
  • Nasrum Massi
  • Khairuddin Djawad
  • Sri Vitayani
  • Nesyana Nurmadilla

DOI:

https://doi.org/10.37506/ijfmt.v15i2.14705

Keywords:

Mangosteen Pericarp Extract, 8 OHdG, Mice Skin, Ultraviolet B

Abstract

Objective: This study aims to determine the effect of the application of mangosteen pericarp extract cream
(Garcinia Mangostana L) on levels of 8-OHdG on the skin of mice after exposure to UVB.
Method: The study use a pure animal experimental research design with control group. The criteria for
inclution were species Swiss albino mice, aged 6 – 9 weeks, weight 20-30 g, female gender and healthy.. The
samples that met the criteria were divided into 5 groups : UVB, Base Cream plus UVB, 3 groups mangosteen
pericarp extract cream with different concentration UVB radiation in mice using a 311 nm narrowband UVB
(Dermalight 1000) with the power 450 mJ/cm three times a week for 4 week. Elisa examination was carried
out before and after the experiment.
Result: This study used 25 mice albino selected randomly and were divided into 5 treatment group
consisting of 5 group : UVB alone, UVB with base cream, UVB with mangosten pericarp extract cream with
concentration of 1 %, 3 % and 5 %. The Comperative test levels of 8-OhdG between each group with Post
Hoc test and found It was concluded that the decrease in OhdG was greatest in group 2 followed by groups
5, 4, 3, and 1 (control group), respectively.
Conclution: The ELISA levels of 8-OHdG was found that there are significant difference as between the
various treatment groups (p>0,05). However, the increasing concentration of mangosten pericarp extract
cream showed decreased level of 8-OHdG.

Author Biographies

Dian Amelia Abdi

Research in Postgraduate Program, Medical Faculty, Hasanuddin University, Indonesia,

Lecturer Department
of Dermatovenereology, Faculty of Medicine, Muslim Indonesia University, Makassar, Indonesia

Nasrum Massi

Assistant
Professor Department of Microbiology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia

Khairuddin Djawad

Assistant Professor Department of Dermatovenereology, Faculty of Medicine, Hasanuddin University, Makassar,
Indonesia

Sri Vitayani

Lecturer Department
of Dermatovenereology, Faculty of Medicine, Muslim Indonesia University, Makassar, Indonesia

Nesyana Nurmadilla

Lecturer Department of Nutrition, Faculty of Medicine, Muslim Indonesia University, Makassar,
Indonesia

Published

2021-03-24

How to Cite

Dian Amelia Abdi, Nasrum Massi, Khairuddin Djawad, Sri Vitayani, & Nesyana Nurmadilla. (2021). Effect of Photoprotective Cream of Mangosteen Pericarp Extract (Garcinia Mongostana L) Against 8-OHdG After UVB Exposure On Albino Mice . Indian Journal of Forensic Medicine & Toxicology, 15(2), 2240-2244. https://doi.org/10.37506/ijfmt.v15i2.14705