The Effect of Nitric Oxide Supplement Intake on the Value of Hematological Examination of Health Workers Exposed to Covid-19

Abstract

Objective: Examination of the diagnostic covid-19 gold standard with real time reverse polymerase chain
reaction (RT-PCR) is still limited, so that the initial hematological examination (leukocytes, lymphocytes,
neutrophils, platelets, hemoglobin, and neutrophil lymphocyte ratio (NLR) plays an important role in
monitoring the course of covid-19 disease Macrophages release nitric oxide (NO) to kill parasites NO
inhibits migration and adhesion of leucocytes to the endothelium. Metode: The research design used preexperimental with one group pre-post test, the total sample was 80 health workers who were exposed to
Covid-19, the independent variable was the provision of NO and the dependent variable was the result of
a hematological examination (leukocytes, lymposites, platelets, neutrophils, hemoglobin and NLR). The
intervention was given NO 500 mg mixed with warm water 250 cc, given 3 times a day for 5 days, data
analysis used the T-test with a significance value of a<0.05. Results: There is a difference in the results
of the pre and post-test hematology giving NO to the results of the examination of leucocytes a=0.001,
lymphocytes a=0.000, platelets a=0.000, neutrophils a=0.000, hemoglobin a=0.031, and NLR a=0.000.
Conclusion: Giving NO to health workers exposed to Covid-19 can improve the hematology and immune
systems to fight the corona virus.