Ketogenic Diet Slows Down Weight Gain in Juvenile Mus musculus with Benzopyrene as Cancer Inducer
Keywords:ketogenic diet, weight gain, benzopyrene induced, ketone, blood glucose
Objective: This study aims to analyze the ketogenic diet that slows down weight gain in juvenile Mus
musculus induced with benzopyrene (BZP). Method: Thirty-six female mice (Mus musculus), 6-8 weeks old,
weighted 15-25 grams were divided into six groups randomly. K1 (negative control, standard diet) induced
with oleum olivarum, while K2 (positive control, standard diet), P1 (ketogenic diet 1), P2 (ketogenic diet 2),
P3 (ketogenic diet 3) and P4 (ketogenic diet 4) induced with BZP subcutaneously in the right breast at a dose
of 0.3mg/20gBB/day for 14 days. The ketogenic diet was given for the next 28 days. Data were analyzed
using the ANOVA and post hoc LSD test. Results: After 42 days, the ketogenic diet mice experienced
slower weight gain (p=0.000) because BZP induced neurotoxicity and the administration of the ketogenic
diet in juvenile mice induced neurohormonal changes. The ketogenic diet increased ketone plasma level
(p=0.000) and reduced blood glucose levels (p=0.002) due to nutritional ketosis state. Conclusions: The
ketogenic diet with fat:protein ratio 60:30 slows down weight gain, increased ketone levels and decreased
blood glucose levels in juvenile mice with BZP as cancer inducer.
How to Cite
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Re use and mixing of content policy- We follow Creative Commons Licence Policy. We follow CC BY. Please refer below for all details
This license lets others distribute, remix, adapt, and build upon our work, even commercially, as long as they credit us for the original creation.
- The journal allows readers to read, download, copy, distribute, print, search, or link to the full texts of its articles and allow readers to use them for any other lawful purpose.
- The journal allows the author(s) to hold the copyright without restrictions.
- The journal allows the author(s) to retain publishing rights without restrictions