Therapeutic Effect of Gum Arabic on some Biochemical Parameters in Nephrotoxic Albino rats

Authors

  • Eman Aboud Hussein
  • Husham Qassim Mohammed

DOI:

https://doi.org/10.37506/ijfmt.v15i2.14713

Keywords:

Gum Arabic, Biochemical, Hematological, nephrotoxic, Albino rat

Abstract

The aim of the current study is to evaluate some biochemical parameters in rats treated with gentamicin
to induce nephrotoxicity . The experimental study was conducted using 42 healthy adult male rat weighing
250-300 grams . The results showed a significant increase (P?0.05) in the levels of urea and creatinine in
the blood serum, an increase in the activity of liver enzymes AST, ALT, ALP and a significant decrease in
the concentration of albumin in adult male rats injected with gentamicin (80 mg / kg IP daily for 10 Days)
to induce nephrotoxicity compared to control group. The results showed a significant increase (P?0.05)
in the concentration of urea and creatinine in the blood serum and a significant increase (P?0.05) in the
activity of liver enzymes AST, ALT, ALP, and albumin concentration in (untreated induced nephrotoxicity)
compared with (control group). The results showed a significant decrease (P?0.05) in the levels of urea
and creatinine in the blood serum and a significant decrease (P?0.05) in the activity of liver enzymes AST,
ALT, ALP, kidney weight and a significant increase (P?0.05) in albumin concentration, from the induced
nephrotoxicity group treated with (15% w / v / day) Gum Arabic compared to the untreated nephrotoxic
group, but the values In all treated groups were less than the control group. The present study concluded that
the induced nephrotoxicity group treated with Gum Arabic showed improvement in some biochemical and
hematological parameters associated mainly with nephrotoxicity

Author Biographies

Eman Aboud Hussein

Research Scholar, Physiology and Pharmacology Department/ College of Veterinary Medicine/ University of
Kufa

Husham Qassim Mohammed

Asst. Professor, University of Kufa , Faculty of Nursing, Najaf, Iraq

Published

2021-03-24

How to Cite

Eman Aboud Hussein, & Husham Qassim Mohammed. (2021). Therapeutic Effect of Gum Arabic on some Biochemical Parameters in Nephrotoxic Albino rats . Indian Journal of Forensic Medicine & Toxicology, 15(2), 2297-2303. https://doi.org/10.37506/ijfmt.v15i2.14713