Immune Dysregulation in Childhood Leprosy

Authors

  • Flora Ramona Sigit Prakoeswa
  • Budi Prasetyo
  • Santi Martini
  • Hardyanto Soebono
  • Muhammad Yulianto Listiawan
  • Anang Endaryanto
  • Cita Rosita Sigit Prakoeswa

DOI:

https://doi.org/10.37506/ijfmt.v15i2.14725

Keywords:

Immune dysregulation, Childhood leprosy

Abstract

Leprosy is a chronic infection which is caused by Mycobacterium leprae. Leprosy has long been considered
a complex disease, in which host and environmental characteristics are as important as the pathogen to
determine disease outcome. Leprosy is an excellent model for examining the immunoregulatory functions.
Children are believed to be the most vulnerable group to leprosy infection due to their immature immunity.
This review is aimed to summarize the findings of previous studies about immune dysregulation in childhood
leprosy. This study highlighted the plausible maternal-fetal connection which are related in immune
dysregulation in childhood leprosy.

Author Biographies

Flora Ramona Sigit Prakoeswa

Doctoral Program, Faculty of Medicine, Airlangga University, Indonesia, Department of Dermatology and
Venereology, Faculty of Medicine, Universitas Muhammadiyah Surakarta, Indonesia

Budi Prasetyo

Associate Professor,
Department of Obstetrics and Gynecology, Faculty of Medicine, Airlangga University / Dr. Soetomo General
Academic Hospital, Surabaya, Indonesia

Santi Martini

Associate Professor, Faculty of Public Health, Airlangga University,
Indonesia

Hardyanto Soebono

Professor, Department of Dermatology and Venereology, Faculty of Medicine, Public Health and
Nursing, Gadjah Mada University, Indonesia

Muhammad Yulianto Listiawan

Associate Professor, Department of Dermatology and Venereology,
Faculty of Medicine, Airlangga University / Dr. Soetomo General Academic Hospital, Surabaya, Indonesia

Anang Endaryanto

Associate Professor, Department of Pediatrics, Faculty of Medicine, Airlangga University / Dr. Soetomo General
Academic Hospital, Surabaya, Indonesia

Cita Rosita Sigit Prakoeswa

Professor, Department of Dermatology and Venereology, Faculty of
Medicine, Airlangga University / Dr. Soetomo General Academic Hospital, Surabaya, Indonesia

Published

2021-03-24

How to Cite

Flora Ramona Sigit Prakoeswa, Budi Prasetyo, Santi Martini, Hardyanto Soebono, Muhammad Yulianto Listiawan, Anang Endaryanto, & Cita Rosita Sigit Prakoeswa. (2021). Immune Dysregulation in Childhood Leprosy . Indian Journal of Forensic Medicine & Toxicology, 15(2), 2356-2364. https://doi.org/10.37506/ijfmt.v15i2.14725

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