The D614G Mutation in Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Spike Glycoprotein: A MiniReport
Keywords:COVID-19, D614G Mutation, SARS-CoV-2.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a quickly spreading virus that poses
a major burden on global human health. Thus, it is essential to develop COVID-19 vaccines. Vaccine
development might not be easy, as a consequence of mutations. This study aimed to demonstrate the D614G
mutation in SARS-CoV-2 spike glycoprotein from Indonesia. 102 isolates from the GISAID EpiCoV
database and the Wuhan-Hu-1 isolate (reference sequence) from GenBank, NCBI were used in this study.
BioEdit employed to examine the D614G mutation in the spike glycoprotein of SARS-CoV-2. In this report,
there are 56 D614G mutations among 102 SARS-CoV-2 isolates. In summary, this report might suggest
that the D614G mutation implicates the COVID-19 pandemic in Indonesia. Nevertheless, this report was a
preliminary study and this study recommends expanding molecular epidemiology and surveillance programs
to monitor COVID-19
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