Green Tea Suppresses Serum TNF-? and TGF-?1 Levels In Mice Model of Systemic Lupus Erythematosus

Abstract

Objective: This study aims to investigate the effects of green tea administration on TNF-a, Hsp70, and
TGF-b1 levels in the systemic lupus erythematosus (SLE). Material and methods: A total of 32 mice
will be divided into four groups (each 8 mice), namely the control group, the SLE group, the SLE group
who were given green tea extract at a dose of 500 mg/kg body weight, and the SLE group who were given
green tea extract at a dose of 1000 mg/kg body weight. Analysis of TNF-a, Hsp70, and TGF-b1 levels was
carried out using the enzyme-linked immunosorbent assay technique. Results: TNF-a and TGF-b1 levels
were significantly increased in the SLE group compared to the control group (p < 0.05). This increase can
be significantly reduced through the provision of green tea, even reaching levels comparable to the control
group (p > 0.05). Conclusions: It was concluded that green tea containing EGCG can suppress TNF-a and
TGF-b1 in the SLE model. Thus, green tea can be an alternative in immunology modulation in SLE.