Green Tea Suppresses Serum TNF-? and TGF-?1 Levels In Mice Model of Systemic Lupus Erythematosus

Authors

  • Herin Mawarti
  • Jusak Nugraha
  • Djoko Agus Purwanto
  • Joewono Soeroso

DOI:

https://doi.org/10.37506/ijfmt.v15i2.14746

Keywords:

green tea; SLE; inflammation; EGCG; stress protein

Abstract

Objective: This study aims to investigate the effects of green tea administration on TNF-a, Hsp70, and
TGF-b1 levels in the systemic lupus erythematosus (SLE). Material and methods: A total of 32 mice
will be divided into four groups (each 8 mice), namely the control group, the SLE group, the SLE group
who were given green tea extract at a dose of 500 mg/kg body weight, and the SLE group who were given
green tea extract at a dose of 1000 mg/kg body weight. Analysis of TNF-a, Hsp70, and TGF-b1 levels was
carried out using the enzyme-linked immunosorbent assay technique. Results: TNF-a and TGF-b1 levels
were significantly increased in the SLE group compared to the control group (p < 0.05). This increase can
be significantly reduced through the provision of green tea, even reaching levels comparable to the control
group (p > 0.05). Conclusions: It was concluded that green tea containing EGCG can suppress TNF-a and
TGF-b1 in the SLE model. Thus, green tea can be an alternative in immunology modulation in SLE.

Author Biographies

Herin Mawarti

Doctoral Student. Doctoral Program of Medical Science, Faculty of Medicine, Airlangga University, Indonesia,

Assistant Professor,
Department of Nursing Science, Faculty of Health Sciences, University of Pesantren Tinggi Darul Ulum, Jombang,
Indonesia

Jusak Nugraha

Professsor, Department of Clinical Patology, Faculty of Medicine, Airlangga University, Indonesia

Djoko Agus Purwanto

Professsor,
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Airlangga University, Indonesia

Joewono Soeroso

Professsor,
Department of Internal Medicine, Faculty of Medicine, Airlangga University, Indonesia

Published

2021-03-24

How to Cite

Herin Mawarti, Jusak Nugraha, Djoko Agus Purwanto, & Joewono Soeroso. (2021). Green Tea Suppresses Serum TNF-? and TGF-?1 Levels In Mice Model of Systemic Lupus Erythematosus. Indian Journal of Forensic Medicine & Toxicology, 15(2), 2488-2494. https://doi.org/10.37506/ijfmt.v15i2.14746