Immunohistochemical Expression of Myeloid Differentiation Adaptor Protein-88(MYD-88 )and Toll like Receptor (TLR-4) in Human Leiomyomas

Authors

  • Huda Saddon Jassim
  • Ali Yhea Salman
  • Sajid saad mohanned

DOI:

https://doi.org/10.37506/ijfmt.v15i2.14755

Keywords:

Leiomyomas, TLR4, MYD-88, Myometrium,Immunohistochemistry

Abstract

Leiomyomas are the most common benign tumor of the female reproductive tract. The aim of this study was
to explore the role of TLR4/ MYD-88signaling pathway in the pathogenesis of leiomyomas. Benign nature
and smooth muscle origination of leiomyomas was easily documented via histological examination, in this
cross-sectional study of 20 conventional leiomyomas cases TLR4/ MYD-88 antibody status was positive in
90% for TLR-4 and in 95% for MYD-88 of leiomyomas. Leiomyomas were stained with TLR4/ MYD-88
marker more than those in normal myometrium cases (P<0.001). In conclusion leiomyomas growth may be
associated with TLR4 and MyD88 expression

Author Biographies

Huda Saddon Jassim

Asisst. Prof. Department of Microbiology/ College of Veterinary Medicine/ University of Baghdad

Ali Yhea Salman

Asisst. Prof. Department of Microbiology/ College of Veterinary Medicine/ University of Baghdad

Sajid saad mohanned

Lecture, Consultant, Histopathology Unit/ Laboratory Department/ Al-yarmouk Teaching Hospital

Published

2021-03-24

How to Cite

Huda Saddon Jassim, Ali Yhea Salman, & Sajid saad mohanned. (2021). Immunohistochemical Expression of Myeloid Differentiation Adaptor Protein-88(MYD-88 )and Toll like Receptor (TLR-4) in Human Leiomyomas. Indian Journal of Forensic Medicine & Toxicology, 15(2), 2542-2550. https://doi.org/10.37506/ijfmt.v15i2.14755