Immunohistochemical Expression of Myeloid Differentiation Adaptor Protein-88(MYD-88 )and Toll like Receptor (TLR-4) in Human Leiomyomas
Keywords:Leiomyomas, TLR4, MYD-88, Myometrium,Immunohistochemistry
Leiomyomas are the most common benign tumor of the female reproductive tract. The aim of this study was
to explore the role of TLR4/ MYD-88signaling pathway in the pathogenesis of leiomyomas. Benign nature
and smooth muscle origination of leiomyomas was easily documented via histological examination, in this
cross-sectional study of 20 conventional leiomyomas cases TLR4/ MYD-88 antibody status was positive in
90% for TLR-4 and in 95% for MYD-88 of leiomyomas. Leiomyomas were stained with TLR4/ MYD-88
marker more than those in normal myometrium cases (P<0.001). In conclusion leiomyomas growth may be
associated with TLR4 and MyD88 expression
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