Comparison of Histological Changes in Mice Infected with the Cryptosporidium Parvum after Treatment with an Aquatic Leaf Extract of Salvia Officinalis, Pimpinella Anisum and, Spiramycin Drug
Keywords:Cryptosporidium, plants extract, histological changes, Spiramycin
Background: Cryptosporidium parvum was cause Cryptosporidiasis .In this study the therapeutic effect
of two aquatic extracts of plants in infected white mice with the C. parvum were examined and the results
were compare with the therapeutic effect of Spiramycin through the study of the histological changes in
mouse intestine. Methods: Thirty male mice were divided into six groups: group 1(non infected, negative
control ), group 2 (feeding with C. parvum oocysts, positive control ), group 3 (infected and treatment with
leaf extract of Pimpinella anisum), group 4 (infected and treated with Salvia officinalis extract ,the group
5 and 6 (infected and treatment with 5mg and 10mg Spiramycin Respectively ) The existence of oocysts
in the feces of animals was counted daily during the therapeutic period .After two weeks; the changes of
cecum histological sections were examined. Conclusions: The oocysts counted in feces samples, showed
significant differences between the treatments (P <0.05). The cecum histological changes in the group 3
and 4 indicated that leaf extract of plants have moderate efficacy in treatment of C.parvum infection. The
cecum appears close to normal at the concentration of 5mg Spiramycin there is no abnormal tissue in the
concentration of 10 mg.
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