Cardiac Arrest Induced by Anti-hypertensive and NSAIDS Drug Abuse Uses due to their Role Effect on Electrolytes and Aldosterone Levels in Hypertensive Patients with Renal Insufficiency

Authors

  • Khama’al Hussein abod Al-Khafaji
  • Ahmed Al-mukhtar
  • Ali Hassan Abood
  • Hydar M khalfa

DOI:

https://doi.org/10.37506/ijfmt.v15i2.14778

Keywords:

ACEI, Aldosterone, NSAIDs, Potassium, Sodium

Abstract

The present study aims to investigate the role of the drugs like angiotensin converting enzyme inhibitors
(ACEI), non-steroidal anti-inflammatory drugs NSAIDs and their effects in the contributions of electrolyte
fluctuation levels, as well as in an abuse uses. Forty four cardiac arrest subjects cases of hypertensive with
renal failure (renal insufficiency) were taken, and forty participants as a healthy control without any heart
and kidney problems with same of mean age (58±5). Done in Hilla city/Iraq were enrolled in this study.
Results that collected from the present study were a significant in reduction of serum aldosterone levels,
with very clear raises in plasma potassium and urinary sodium levels due to the action of hypertension drugs.
Also results shown a significant decreases in the urinary potassium, otherwise plasma sodium levels within
the normal elevated malady in patients, when compared with healthy control. There were significance results
with moderately increases levels of the patient serums urea and creatinine, as when correlated with healthy
control investigations. The current study found that BMI does not differ in patient groups (with cardiac
arrest) when compared with the normal healthy control group and each were within the BMI range for
normal weight of a person both in males and females. It was concluded that uses of antihypertensive drugs
and NSAIDs lead to lowering aldosterone levels that relates hypertension treatments and inflammatory
diseases.

Author Biographies

Khama’al Hussein abod Al-Khafaji

Asst. Professor, Faculty of Pharmacy, University of Kufa, Iraq

Ahmed Al-mukhtar

Research Scholar, Corresponding Author, Central
laboratory department, Babylon health directorate, Babylon, Iraq

Ali Hassan Abood

Asst. Professor, Department of Biology, Faculty
of Science, University of Kufa, Najaf, Iraq

Hydar M khalfa

Asst. Professor, Department of Biology, Faculty of Science, University
of Kufa, Najaf, Iraq

Published

2021-03-24

How to Cite

Khama’al Hussein abod Al-Khafaji, Ahmed Al-mukhtar, Ali Hassan Abood, & Hydar M khalfa. (2021). Cardiac Arrest Induced by Anti-hypertensive and NSAIDS Drug Abuse Uses due to their Role Effect on Electrolytes and Aldosterone Levels in Hypertensive Patients with Renal Insufficiency. Indian Journal of Forensic Medicine & Toxicology, 15(2), 2681-2686. https://doi.org/10.37506/ijfmt.v15i2.14778