Time-dependent Expression of Caspase-3 and Degeneration of Lateral Rectus Muscle on Experimental Esotropia in Rabbits
Keywords:caspase-3, degeneration of lateral rectus muscle, esotropia, rabbit
Background: To identify correlation between caspase-3 expression and degeneration of lateral rectus muscle
on experimental esotropia in rabbits by using time dependent analysis. Methods: Twenty four rabbits were
divided into 4 groups, first month sham (S1); second month sham (S2); first month esotropia (E1); and
second month esotropia (E2) model groups. Immunohistochemical and haematoxyllin eosin staining were
performed. Results: In first month observation no significant difference in caspase-3 expression between S1
(1.56 ± 1.03) and E1 (3.93 ± 1.66) groups (p >0.05) and in the degeneration score of lateral rectus muscle
between S1 (1.33 ± 1.36) and E1 (3.83 ± 2.04) groups (p> 0.05). In second month observation no significant
difference in caspase-3 expression between S2 (1.80 ±1.08) and E2 (6.50 ± 3.26) groups (p >0.05); but
there was significant difference in the degeneration score of lateral rectus muscle between S2 (1.16 ± 1.16)
and E2 (4.50 ± 1.04) groups (p <0.05). There was a significant correlation between caspase-3 expression
and the degeneration score of lateral rectus muscle (p=0.020; r=0.471). Conclusion: On the experimental
esotropia with prolonged lateral muscle contraction in rabbits, the increasing trend of caspase-3 expression
has a correlation with the increasing degeneration score of lateral rectus muscle.
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