Do Lab Parameter Could be used as Indicators of Severity in Case of Acute Cholinestrase Inhibitor Insecticides?

Authors

  • Makloph MG
  • Ghada Mustafa El-Gallad
  • Mahmoud Lotfy Sakr
  • Ahmed Salah Eid El-Sayed

DOI:

https://doi.org/10.37506/ijfmt.v15i2.14794

Keywords:

Amylase, , C-Reactive Protein , Lactate Dehydrogenase, Peradynia organophosphorus poisoning scale.

Abstract

Background: Cholinestrase inhibitor insecticides considered one of the most common causes of morbidity
and mortality due to poisoning especially in developing countries like Egypt. This work aims to study
the possible role of Creatine Phosphokinase (CPK), Amylase, Lactate Dehydrogenase (LDH), C-Reactive
Protein (CRP) and blood sugar status in predicting the severity of acute cholinesterase inhibitor insecticides
poisoning at the time of admission.
Subjects and Methods: This work was done at Poison Control Center of Ain Shams University Hospitals –
Egypt, and was carried on 150 patients admitted with acute (CEI) insecticides poisoning. Clinical evaluation
of the patients and poisoning severity was graded according to Peradynia organophosphorus poisoning
(POP) scale, then venous blood sample was collected from patients and examined for CPK, Amylase, LDH,
CRP and random blood sugar (RBS).
There is significant increase of CPK, LDH, CRP RBS and amylase enzyme specially with increase the
severity in those patients admitted to ICU rather than inpatient, and in mechanically ventilated patients
rather than non mechanically ventilated and in died patients rather than survivors.
Conclusion: CPK, Amylase, LDH, CRP and random blood sugar could be used to predict severity of
cholinesterase inhibitor insecticides poisoning. They can also predict ICU admission, mechanical ventilation
need and mortality. Amylase is a better predictor of respiratory failure and need of mechanical ventilation.

Author Biographies

Makloph MG

Lecturer of forensic Medicine and Clinical Toxicology Department of Forensic Medicine And Clinical Toxicology,
Fayoum University

Ghada Mustafa El-Gallad

Professor of Forensic Medicine And Clinical Toxicology Department of Forensic Medicine
And Clinical Toxicology, Fayoum University

Mahmoud Lotfy Sakr

Professor of Clinical Toxicology Poison Control Center, Ain Shams
University Hospitals

Ahmed Salah Eid El-Sayed

Assistant Lecturer of Forensic Medicine And Clinical Toxicology Department Of Forensic
Medicine And Clinical Toxicology, Fayoum University

Published

2021-03-24

How to Cite

Makloph MG, Ghada Mustafa El-Gallad, Mahmoud Lotfy Sakr, & Ahmed Salah Eid El-Sayed. (2021). Do Lab Parameter Could be used as Indicators of Severity in Case of Acute Cholinestrase Inhibitor Insecticides?. Indian Journal of Forensic Medicine & Toxicology, 15(2), 2786-2794. https://doi.org/10.37506/ijfmt.v15i2.14794