Do Lab Parameter Could be used as Indicators of Severity in Case of Acute Cholinestrase Inhibitor Insecticides?
Keywords:Amylase, , C-Reactive Protein , Lactate Dehydrogenase, Peradynia organophosphorus poisoning scale.
Background: Cholinestrase inhibitor insecticides considered one of the most common causes of morbidity
and mortality due to poisoning especially in developing countries like Egypt. This work aims to study
the possible role of Creatine Phosphokinase (CPK), Amylase, Lactate Dehydrogenase (LDH), C-Reactive
Protein (CRP) and blood sugar status in predicting the severity of acute cholinesterase inhibitor insecticides
poisoning at the time of admission.
Subjects and Methods: This work was done at Poison Control Center of Ain Shams University Hospitals –
Egypt, and was carried on 150 patients admitted with acute (CEI) insecticides poisoning. Clinical evaluation
of the patients and poisoning severity was graded according to Peradynia organophosphorus poisoning
(POP) scale, then venous blood sample was collected from patients and examined for CPK, Amylase, LDH,
CRP and random blood sugar (RBS).
There is significant increase of CPK, LDH, CRP RBS and amylase enzyme specially with increase the
severity in those patients admitted to ICU rather than inpatient, and in mechanically ventilated patients
rather than non mechanically ventilated and in died patients rather than survivors.
Conclusion: CPK, Amylase, LDH, CRP and random blood sugar could be used to predict severity of
cholinesterase inhibitor insecticides poisoning. They can also predict ICU admission, mechanical ventilation
need and mortality. Amylase is a better predictor of respiratory failure and need of mechanical ventilation.
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