Potassium Sorbate Induces Oxidative Stress and Genotoxicity in Human Lymphocytes

Authors

  • Malinee Pongsavee
  • Rajnikant Mishra

DOI:

https://doi.org/10.37506/ijfmt.v15i2.14795

Keywords:

Potassium sorbate, Genotoxicity, Oxidative stress, Lymphocytes.

Abstract

Potassium sorbate, a potassium salt of sorbic acid, has been used as food preservative and antimicrobial agent.
Some observations in rat and hamster cells suggest its toxicity. However, observations in human cells are
limiting. Therefore, it has been intended to investigate impacts of potassium sorbate on human lymphocytes.
The lymphocytes were cultured and treated with 0.5, 1.0, 1.5 and 2.0 mg/ml of potassium sorbate for 24 and
48 h. Evaluations of its impacts were done through the MTT assay, analysis of chromosomal aberrations,
formation of micronucleus and activities of superoxide dismutase. The results revealed that potassium
sorbate induced oxidative stress, genotoxicity, damages to chromosome, formation of micronucleus in
human lymphocytes.

Author Biographies

Malinee Pongsavee

Associate Professor, Department of Medical Technology, Faculty of Allied Health Sciences, Thammasat
University, Rangsit Campus, Patumthani, Thailand

Rajnikant Mishra

Professor, Biochemistry and Molecular Biology Laboratory,
Department of Zoology, Institute of Science, Banaras Hindu University, Varanasi, India

Published

2021-03-24

How to Cite

Malinee Pongsavee, & Rajnikant Mishra. (2021). Potassium Sorbate Induces Oxidative Stress and Genotoxicity in Human Lymphocytes. Indian Journal of Forensic Medicine & Toxicology, 15(2), 2795-2803. https://doi.org/10.37506/ijfmt.v15i2.14795