A Study of Acute Renal Failure in the Users of Proton Pump Inhibitors
Keywords:Renal failure, acute, Proton pump inhibitors users
Background: Proton pump inhibitors are one of the most common classes of medications that act by inhibiting
gastric H+/K+ adenosine triphosphatase via covalent binding to the cysteine residues of the proton pump,
they provide the most potent acid suppression available. Lansoprazole, pantoprazole, and dexlansoprazole
have the greatest bioavailability and achieve the highest plasma levels. Rabeprazole is the most acid-labile
PPI and therefore the most potent, whereas pantoprazole is the least reactive and therefore the least potent
Patients and methods: Research data were collected from Al-zahraa teaching hospital/ Wasit province and
Morgan teaching hospital/ Babylon province, they include patients with acute renal failure who used/ using
proton pump inhibitors compared with those do not use proton pump inhibitors to know the probable relation
between acute renal failure and the use of proton pump inhibitors. Results and discussion: Results showed
that only 30 patients of 120 patients with acute renal failure consult the hospital were PPIs users, this may
refer to presence of a relationship between proton pump inhibitor and acute Renal failure . Previous studies
in this field referred to a similar relationship, a case reports and a recent case series implicating these drugs
in acute interstitial nephritis (AIN) and progression to acute renal failure.
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