Association of Serum Galectin-3 Level with Albuminuria and Renal Function in Type 2 Diabetic Iraqi Patients
Keywords:galectin-3, albuminuria,T2DM; tpxicity; health .
Background: Galectin-3 is a category of ?- galactoside binding Lectin. It has been involved in renal
inflammation and fibrosis. We examined the relationship between galectin-3 level and nephropathy in T2DM
patients with or without microalbuminuria in comparison healthy controls.
Methods: Ninety T2DM patients they were graded as (3 groups) depending on (ACR) albumin to creatinine
value: normalbuminuria (ACR < 30 mg / g), micro albuminuria (ACR 30-300 mg / g); and macroalbuminuria
(ACR > 300 mg / g). In addition, 30 healthy control subject. The serum galectin-3 was determined by an
enzyme-linked immune sorbent assay (ELISA) for 90 T2DM patients and 30 healthy subjects. And also
biochemical parameters measured included FBG, HbA1c, urea, creatinine, and uric acid.
Result: Serum galectin-3 was significantly raised in T2DM patients with macroalbuminuria in comparing to
healthy group and also to other patients groups (p<0.001). Galectin-3 level was positively related with each
of ACR, FBS, HbA1c, urea, creatinine. whilst, eGFR was negatively correlated with galectin-3
Conclusion: Galectin-3 level is essentially higher with T2DM at all stages of DN, particularly in
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