Thyroid Pathological Consequences Induced by Caffeine in Female Rats
Keywords:caffeine, thyroid hypo-function, histopathology, toxicity
Objective: this study was designed to investigate the histopathological changes induced by caffeine on
thyroid, liver and kidneys in female rats. Caffeine is a central nervous stimulant of methyl xanthine class of
drugs, it has many hormonal and metabolic effects.
Method: twenty-four adult female rats was split in to four equal categories of 6 rats in each group as the
following: Group1,control group received distilled water only by oral gavage. Group2, received 35mg\kg of
caffeine solution. Group3, received 75mg\kg of caffeine and Group4, received 150mg\kg of caffeine. The
experiment continued for 40 days. After 24 hours of the end of experiment, the animals were sacrificed and
blood has been withdrawn from vena cava to prepare serum for hormonal analysis, whereas liver, kidneys
and thyroid were excised and fixed in formalin solution for histopathological processing.
Results: caffeine ingestion cause significant reduction in thyroid function (reduction in T3, T4 and TSH)
in all treated groups compared to control group in addition histopathological study show enlargement of
thyroid follicle with thinning of lining epithelium of acini, vacuolation of both renal tubules, hepatocytes
and vascular congestion of these organs.
Conclusion: Caffeine consumption in high doses causes many histologic and hormonal effects in the studied
How to Cite
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Re use and mixing of content policy- We follow Creative Commons Licence Policy. We follow CC BY. Please refer below for all details
This license lets others distribute, remix, adapt, and build upon our work, even commercially, as long as they credit us for the original creation.
- The journal allows readers to read, download, copy, distribute, print, search, or link to the full texts of its articles and allow readers to use them for any other lawful purpose.
- The journal allows the author(s) to hold the copyright without restrictions.
- The journal allows the author(s) to retain publishing rights without restrictions