The Use of Pentoxifylline Topical in the Treatment of Alopecia in Rats
Keywords:chemotherapy induced alopecia, cyclophosphamide, pentoxifylline, TNF-?, INF-?, IL-13.
Hair is the human body’s major esthetic display component, especially in cultural and social interactions.
Hair loss is yet sometimes transient and the patient restore hair growth but have harmful effect on the
psychology of the patient. Throughout this research, the potency of topical pentoxifylline (PTX) in
stimulating regrowth in hair loss caused by cyclophosphamide was established. The study was performed
by treated with PTX topically in male Swiss albino rats. The animals divided into seven groups with six
animals in each group. To induce alopecia Cyclophosphamide used at a dose of (125 mg/kg) intraperitoneal.
Macroscopically pentoxifylline (PTX) treated groups displayed new hair growth. Strong follicular
proliferation was demonstrated by histopathology and gross morphological observations of hair growth in
shaved areas. The blood biochemical cytokine assay revealed a down regulation of pro inflammatory TH1
cytokines TNF-? and INF-g, in addition there is up regulation of TH2 cytokine IL-13. In the study showed
an efficient efficacy on the treatment of alopecia induced by cyclophosphamide.
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