Role of Preconditioning Adipose Mesenchymal Stem Cells in Regeneration Disk: a Review Article

Authors

  • Romaniyanto
  • Hari Basuki Notobroto
  • Cita Rosita Sigit Prakoeswa
  • Fedik Abdul Rantam
  • Dwikora Novembri Utomo
  • Heri Suroto
  • Ferdiansyah

DOI:

https://doi.org/10.37506/ijfmt.v15i2.14892

Keywords:

Adipose-Derived Mesenchymal Stem Cells, Disk Degeneration, Intervertebral Disk, Preconditioning, Regeneration, Stem Cells

Abstract

Intervertebral disk (IVD) degeneration (IDD) is a degenerative disease and often found in daily practice.
The managements that were used so far are only symptomatic and have not been able to solve the disease
completely. The use of mesenchymal stem cells (MSCs) has been widely tested as a solution for the
regeneration of IVD in IDD. Adipose-derived mesenchymal stem cells (ASCs) are one of the sources of
MSCs which were widely studied as an alternative. One of the factors that can influence the efficiency and
capacity of ASCs in IDD cases is preconditioning. Generally, there were three pre-conditioning strategies of
ASCs before being used as therapy, (1) modifying the environment, (2) using Growth Factors, Cytokines,
Chemokines, Hormones, (3) using pharmacological and chemical agents. Preconditioning on ASCs can
change its function in various ways. We tried to link all these things together so that we could know the role
of pre-conditioning ASCs in the regeneration disk.

Author Biographies

Romaniyanto

Doctoral Program, Faculty of Medicine, Airlangga University, Indonesia, Department of Orthopedic and
Traumatology, Faculty of Medicine, Prof. Dr. R. Soerharso Orthopaedic Hospital, Universitas Sebelas Maret,
Solo, Indonesia

Hari Basuki Notobroto

Associate Professor, Faculty of Public Health, Universitas Airlangga, Surabaya, Indonesia

Cita Rosita Sigit Prakoeswa

Professor, Department of Dermatology and Venereology, Faculty of Medicine, Airlangga University / Dr. Soetomo
General Academic Hospital, Surabaya, Indonesia

Fedik Abdul Rantam

Professor, Department of Virology and Immunology, Faculty of
Veterinary Medicine / Stem Cell Research and Development Center, Universitas Airlangga, Surabaya, Indonesia

Dwikora Novembri Utomo

Professor, Department of Orthopedic and Traumatology, Faculty of Medicine, Dr. Soetomo General Academic
Hospital, Universitas Airlangga, Surabaya, Indonesia

Heri Suroto

Associate Professor, Department of Orthopedic and
Traumatology, Faculty of Medicine, Dr. Soetomo General Academic Hospital, Universitas Airlangga, Surabaya,
Indonesia

Ferdiansyah

Associate Professor, Department of Orthopedic and Traumatology, Faculty of Medicine, Dr. Soetomo General Academic Hospital, Universitas Airlangga, Surabaya,
Indonesia

Published

2021-03-24

How to Cite

Romaniyanto, Hari Basuki Notobroto, Cita Rosita Sigit Prakoeswa, Fedik Abdul Rantam, Dwikora Novembri Utomo, Heri Suroto, & Ferdiansyah. (2021). Role of Preconditioning Adipose Mesenchymal Stem Cells in Regeneration Disk: a Review Article. Indian Journal of Forensic Medicine & Toxicology, 15(2), 3345-3352. https://doi.org/10.37506/ijfmt.v15i2.14892

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