Role of Preconditioning Adipose Mesenchymal Stem Cells in Regeneration Disk: a Review Article

Abstract

Intervertebral disk (IVD) degeneration (IDD) is a degenerative disease and often found in daily practice.
The managements that were used so far are only symptomatic and have not been able to solve the disease
completely. The use of mesenchymal stem cells (MSCs) has been widely tested as a solution for the
regeneration of IVD in IDD. Adipose-derived mesenchymal stem cells (ASCs) are one of the sources of
MSCs which were widely studied as an alternative. One of the factors that can influence the efficiency and
capacity of ASCs in IDD cases is preconditioning. Generally, there were three pre-conditioning strategies of
ASCs before being used as therapy, (1) modifying the environment, (2) using Growth Factors, Cytokines,
Chemokines, Hormones, (3) using pharmacological and chemical agents. Preconditioning on ASCs can
change its function in various ways. We tried to link all these things together so that we could know the role
of pre-conditioning ASCs in the regeneration disk.