Role of Ginger Ethanolic Extract in Improving Renal Dysfunction –Induced by Gentamicin
Keywords:Ginger extract , Rats , Renal dysfunctions
Objectives: The present study was designed to evaluate the effect of ethanolic extract of ginger rhizome
in improving renal dysfunction experimentally induced by gentamicin in male rats in order to give an
experimental evidence for its established use. Duration: September 2020- December 2020. Design: In this
study (25) Swiss albino male rats were used weighing (200-230) gm. which were divided randomly into
five equal groups, (5) rats in each group as follows: G1 (control) which was received distilled water orally
daily for 10 days. G2: received therapeutic dose of gentamicin sulphate (5mg/kg) intramuscularly once
daily for 10 days. G3: received two fold dose of gentamicin (10mg/kg) intramuscularly once daily for 10
days. G4: received co-administration of gentamicin (5mg/kg) intramuscularly + ethanolic extract of ginger
rhizome (250 mg/kg) orally daily for 10 days, while the G5: received gentamicin (10mg/kg) + ethanolic
extract of ginger rhizome (250mg/kg) orally daily for 10 days. All the treatments were given in amounts
levels of (0.1/100gm) B.W. Animals from each group were sacrificed at the end of 10 days and blood were
collected and sera were separated for biochemical testes , while the kidneys removed for histopathological
examinations . The findings: Significant increase (P<0.05) in the serum levels of uric acid, creatinine
and blood urea nitrogen (BUN) in (G2&G3) as compared to (G1) group , while there were significant
decrease (P<0.05) in serum levels of these testes in the groups (G4&G5) as compared to ( G2&G3 ) groups
beside normalizing the kidney histopathological architecture . Conclusion: It can be concluded that the coadministration of gentamicin along with ginger rhizome ethanolic extract has been exhibited more activity
in improving renal dysfunctions .
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