Drug Interaction of Hypericum Perforatum with Routine Chemical Drugs


  • Reza Assadzadeh
  • Shabnam Shamaei
  • Aliasghar Manouchehri




Medicinal plant, Hypericum perforatum, Drug interaction, Chemical drug


In traditional medicine, Hypericum perforatum L. is used as an antidepressant, diuretic, analgesic, antiseptic
and wound healing, anticonvulsant, rheumatism and chronic gastrointestinal spasms, abortion, sciatica, and
for the treatment of infectious diseases such as syphilis, tuberculosis, dysentery, pertussis, worm excretion,
and malaria. H. perforatum interferes with cardiac drugs, anesthetics, narcotics and analgesics, antibiotics,
hormonal compounds, antiviral compounds, anticonvulsants and antidepressants, organ transplantation
compounds, and iron compounds. Despite the medicinal effects of the valuable plant H. perforatum, the
single use of this plant is very effective and valuable in the treatment of diseases and disorders, but its use
with other chemical drugs due to the occurrence of drug interactions requires caution in consumption.

Author Biographies

Reza Assadzadeh

Assistant Professor of Nephrology, School of Medicine, Ilam University of Medical Sciences, Ilam, Iran

Shabnam Shamaei

Professor, Department of Chemistry, Islamic Azad University, Khorramabad Branch, Khorramabad, Iran

Aliasghar Manouchehri

Assistant Professor, Department of Internal Medicine, Shahid Beheshti Hospital, Babol University of Medical
Sciences, Babol, Iran



How to Cite

Reza Assadzadeh, Shabnam Shamaei, & Aliasghar Manouchehri. (2021). Drug Interaction of Hypericum Perforatum with Routine Chemical Drugs. Indian Journal of Forensic Medicine & Toxicology, 15(2), 3450-3454. https://doi.org/10.37506/ijfmt.v15i2.14907