Analysis of Platelet Volume Indices in Patients with Acute Coronary Syndrome in Gujarat, India
Keywords:Myocardial infarction, platelet volume indices, coronary artery disease
Background: Coronary artery disease (CAD) is growing in heaps and bounces with increasing incidences
every year due to increase in cardiovascular risk factors like diabetes mellitus, obesity, smoking, hypertension,
dyslipidemia and sedentary life style. Platelets have always been a cornerstone of thrombosis, aggravation
of atherosclerosis and its complications, such as acute coronary syndromes which include acute myocardial
infarction (AMI), Non ST Elevation MI (NSTEMI) and unstable angina (UA), and sudden cardiac death.
Platelet aggregation and activation plays a pivotal role in thrombus generation in cardiovascular diseases.
The aim of this study is to evaluate platelet indices in coronary artery disease and to reveal a clinical
discussion based on them.
Methods: A total of 65 cases were studied; 21 patients had stable coronary artery disease for which they
were admitted for a coronary angiogram. 27 patients had Troponin negative unstable angina (UA) or troponin
positive NSTEMI or STEMI having corresponding ECG findings. The third group had a normal cardiogram.
Conclusion: Platelet Volume Indices studied were — mean platelet volume (MPV), platelet large cell
ratio (PLCR), platelet distribution width (PDW) was increased in ACS as compared to stable CAD and the
control group. Large platelets are functionally notorious and are a predisposing contributor for developing
myocardial infarction. Larger platelets can be diagnosed routinely by CBC’s, Platelet volume indices are
common, cheap and easily available tool for screening future thrombotic cardiovascular diseases.
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