Effect of Oxymetholone on The Sperm Quality and Sex Hormone Profile in Male Rats
Keywords:Oxymetholone, sperm parameters, hormonal profiles.
The objective of present study was to evaluated the effect of Oxymetholone drug on sperm parameters
and sex hormone in adult male rats. Twenty male rats sexually mature were randomly divided into two
groups; Each group has 10 rats. The treated group administered orally with Oxymethololne drug 5 mg/g
body weight/ day of for 60 days while the control group administered orally normal saline per day. SPSS
analysis of data generated with P< 0.05 considered statistically significant. The results showed a significant
decrease (p <0.05) in the mean sperm count, the motility and viability in treated group compared to control.
Also, LH (luteinizing hormone) FSH (follicle stimulating hormone) and T (testosterone) of the treated group
were significantly lowered compared to the control. The administration of Oxymethylene induces low sperm
quality with reduction in sex hormone.
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