Association of Single-nucleotide Polymorphisms rs2243250 of IL4 gene in Diabetes Type 1 Patients with Acute Tonsillitis
Keywords:Interlukine4, Tonsillitis, Diabetes, Gene and Inflammation
Diabetes mellitus type 1 one of diseases which is a difficult metabolism condition, it is characterize high
level of glucose in of the human blood stream and is a consider prolonged autoimmune disease alignment
sever inflammatory factor. The newest studies reveal that innate immunity high role in diabetes type1. The
samples in this study consist of (135) Iraqi male with diabetes type 1 with acute tonsillitis in three group
(G1: 4-18 years, G2: 11-18 years and control) all samples diagnosed by biochemical methods added to the
clinical method. Alleles were determined by amplification of the polymorphic site by real time polymerase
chain reaction. The result of genotyping study of rs2243250 of IL4 revealed that the T allele frequency
showed (0.42 %), (0.41%) and (0.69%) in groups G1,G2, control respectively, while the result revealed that
the allele frequency C in groups G1,G2, control was (0.58%), (0.59%) and (0.31%) respectively. The study
can be concluded that the genetic variation of rs2243250 of IL4 gene was associated with diabetes mellitus
type1 comparison in control (healthy women) in Iraqi men.
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