The Genetic Aspect of Non-Syndromic Cleft Lip and Palate towards Candidate Genes in the Etiology : A literature Review
Keywords:Cleft Lip, Cleft Palate, Genetic
Cleft lip and cleft palate (CL/P) is a cleft lip deformity indicated by an opening or an uncommon cleft in
the lip or roof of the mouth (palate). The differences in ethnicity, gender, and the correlation with genetic
factors influence the prevalence of Non-syndromic CL/P. This study was conducted through a literature
review on genes that were allegedly associated with Non-syndromic CL/P. Genetics play a role, to a greater
or lesser extent, in all diseases. Besides, palatogenesis involves many diverse genes in a complex process.
In this case, oral cleft phenotypes develop when this process is disrupted in some manner because of gene
dysfunction. Various genetic approaches, including genome-wide and candidate gene association studies
as well as linkage analysis, have been undertaken to identify etiologic factors, but results have often been
inconclusive or contradictory. Therefore, it concludes that the genetic basis of CL/P is still controversial
because of the genetic complexity of clefting
How to Cite
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Re use and mixing of content policy- We follow Creative Commons Licence Policy. We follow CC BY. Please refer below for all details
This license lets others distribute, remix, adapt, and build upon our work, even commercially, as long as they credit us for the original creation.
- The journal allows readers to read, download, copy, distribute, print, search, or link to the full texts of its articles and allow readers to use them for any other lawful purpose.
- The journal allows the author(s) to hold the copyright without restrictions.
- The journal allows the author(s) to retain publishing rights without restrictions