The Genetic Aspect of Non-Syndromic Cleft Lip and Palate towards Candidate Genes in the Etiology : A literature Review

Authors

  • Mala Kurniati
  • RM Coen Pramono D
  • Agung Sosiawan
  • Ni Wayan Tirtaningsih

DOI:

https://doi.org/10.37506/ijfmt.v15i2.14935

Keywords:

Cleft Lip, Cleft Palate, Genetic

Abstract

Cleft lip and cleft palate (CL/P) is a cleft lip deformity indicated by an opening or an uncommon cleft in
the lip or roof of the mouth (palate). The differences in ethnicity, gender, and the correlation with genetic
factors influence the prevalence of Non-syndromic CL/P. This study was conducted through a literature
review on genes that were allegedly associated with Non-syndromic CL/P. Genetics play a role, to a greater
or lesser extent, in all diseases. Besides, palatogenesis involves many diverse genes in a complex process.
In this case, oral cleft phenotypes develop when this process is disrupted in some manner because of gene
dysfunction. Various genetic approaches, including genome-wide and candidate gene association studies
as well as linkage analysis, have been undertaken to identify etiologic factors, but results have often been
inconclusive or contradictory. Therefore, it concludes that the genetic basis of CL/P is still controversial
because of the genetic complexity of clefting

Author Biographies

  • Mala Kurniati

    Post Graduate, Doctoral Program, Faculty of Medicine, Universitas Airlangga, Surabaya-Indonesia

  • RM Coen Pramono D

    Professor, Department
    of Oral & Maxillofacial Surgery, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia

  • Agung Sosiawan

    Senior Lecterur, Department of Dental Public Health, Faculty of Dental Medicine, Universitas Airlangga,
    Surabaya, Indonesia

  • Ni Wayan Tirtaningsih

    Senior Lecterur, Department of Anatomy and Histology, Faculty of Medicine, Universitas
    Airlangga, Surabaya, Indonesia

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Published

2021-03-24

How to Cite

The Genetic Aspect of Non-Syndromic Cleft Lip and Palate towards Candidate Genes in the Etiology : A literature Review. (2021). Indian Journal of Forensic Medicine & Toxicology, 15(2), 3610-3613. https://doi.org/10.37506/ijfmt.v15i2.14935